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Title: Fatty acid and mineral receptors as drug targets for gastrointestinal disorders
Authors: Pawin Pongkorpsakol
Aekkacha Moonwiriyakit
Chatchai Muanprasat
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Mar-2017
Citation: Future Medicinal Chemistry. Vol.9, No.3 (2017), 315-334
Abstract: © 2017 Future Science Ltd. Nutrient-sensing receptors, including fatty acid receptors (FFA1-FFA4), Ca2+-sensing receptors and Zn2+-sensing receptors, are involved in several biological processes. These receptors are abundantly expressed in the GI tract, where they have been shown to play crucial roles in regulating GI function. This review provides an overview of the GI functions of fatty acid and mineral receptors, including the regulation of gastric and enteroendocrine functions, GI motility, ion transport and cell growth. Recently, several lines of evidence have implicated these receptors as promising therapeutic targets for the treatment of GI disorders, for example, inflammatory bowel disease, colorectal cancer, metabolic syndrome and diarrheal diseases. A future perspective on drug discovery research targeting these receptors is discussed.
ISSN: 17568927
Appears in Collections:Scopus 2016-2017

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