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Title: Tyrosine kinase/phosphatase inhibitors decrease dengue virus production in HepG2 cells
Authors: Thawornchai Limjindaporn
Jutatip Panaampon
Shilu Malakar
Sansanee Noisakran
Pa thai Yenchitsomanus
Mahidol University
Thailand National Center for Genetic Engineering and Biotechnology
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 29-Jan-2017
Citation: Biochemical and Biophysical Research Communications. Vol.483, No.1 (2017), 58-63
Abstract: © 2017 Elsevier Inc. Dengue virus is the causative agent of dengue fever, dengue hemorrhagic fever, and dengue shock syndrome. High rates of dengue virus replication and virion production are related to disease severity. To identify anti-DENV compounds, we performed cell-based ELISA testing to detect the level of DENV E protein expression. Among a total of 83 inhibitors, eight were identified as inhibitors with antiviral activity. Epidermal growth factor receptor inhibitor II (EGFR/ErbB-2/ErbB-4 inhibitor II) and protein tyrosine phosphatase inhibitor IV (PTP inhibitor IV) significantly inhibited dengue virus production and demonstrated low toxicity in hepatocyte cell lines. Our results suggest the efficacy of tyrosine kinase/phosphatase inhibitors in decreasing dengue virus production in HepG2 cells.
ISSN: 10902104
Appears in Collections:Scopus 2016-2017

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