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Title: Cytotoxic tropolones from the fungus Nemania sp. BCC 30850
Authors: Jittra Kornsakulkarn
Siriporn Saepua
Rapheephat Suvannakad
Sumalee Supothina
Nattawut Boonyuen
Masahiko Isaka
Samran Prabpai
Palangpon Kongsaeree
Chawanee Thongpanchang
Thailand National Center for Genetic Engineering and Biotechnology
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry
Issue Date: 1-Jan-2017
Citation: Tetrahedron. Vol.73, No.25 (2017), 3505-3512
Abstract: © 2017 Elsevier Ltd Twelve new compounds, including nine tropolones, nemanolones A−I (1–9), three 7-isochromenones, nemanecins A−C (10–12), and a new naturally isolated 4-isochromanone (13), along with two known compounds, 7,8-dihydroxy-3-methyl isochroman-4-one (XJP), and chaetoquadrin F, were isolated from culture broth of the fungus Nemania sp. BCC 30850. Structures of these compounds were elucidated by NMR and MS spectroscopic analyses. Nemanolones exhibited cytotoxic activities and two of them, compounds 1 and 2, also showed antibacterial activity against Bacillus cereus and antifungal activity against Candida albicans.
ISSN: 14645416
Appears in Collections:Scopus 2016-2017

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