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Title: Epigenetic regulation of noncoding RNA transcription by mammalian RNA polymerase III
Authors: Jong Lyul Park
Yeon Su Lee
Nawapol Kunkeaw
Seon Young Kim
In Hoo Kim
Yong Sun Lee
Korea Research Institute of Bioscience and Biotechnology
University of Science and Technology (UST)
National Cancer Center, Gyeonggi
UT Medical Branch at Galveston
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Feb-2017
Citation: Epigenomics. Vol.9, No.2 (2017), 171-187
Abstract: © 2017 Yong Sun Lee. RNA polymerase III (Pol III) synthesizes a range of medium-sized noncoding RNAs (collectively 'Pol III genes') whose early established biological roles were so essential that they were considered 'housekeeping genes'. Besides these fundamental functions, diverse unconventional roles of mammalian Pol III genes have recently been recognized and their expression must be exquisitely controlled. In this review, we summarize the epigenetic regulation of Pol III genes by chromatin structure, histone modification and CpG DNA methylation. We also recapitulate the association between dysregulation of Pol III genes and diseases such as cancer and neurological disorders. Additionally, we will discuss why in-depth molecular studies of Pol III genes have not been attempted and how nc886, a Pol III gene, may resolve this issue.
ISSN: 1750192X
Appears in Collections:Scopus 2016-2017

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