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Title: A novel method for dengue virus detection and antibody screening using a graphene-polymer based electrochemical biosensor
Authors: Krongkaew Navakul
Chompunuch Warakulwit
Pa thai Yenchitsomanus
Aussara Panya
Peter A. Lieberzeit
Chak Sangma
Kasetsart University
Mahidol University
Universitat Wien
Keywords: Biochemistry, Genetics and Molecular Biology;Chemical Engineering;Engineering
Issue Date: 1-Feb-2017
Citation: Nanomedicine: Nanotechnology, Biology, and Medicine. Vol.13, No.2 (2017), 549-557
Abstract: © 2016 Elsevier Inc. Dengue fever is a major disease that kills many people in the developing world every year. During early infection, a patient displays a high temperature without other signs. After this stage, and without proper treatment, serious damage to internal organs can happen, which occasionally leads to death. A rapid technique for the early detection of dengue virus (DENV) could reduce the number of fatalities. This study presents a new technique for the detection, classification and antibody screening of DENV based on electrochemical impedance spectroscopy (EIS). We found that the charge transfer resistance (Rct) of a gold electrode coated with graphene oxide reinforced polymer was influenced by virus type and quantity exposed on the surface. Molecular recognition capability established during the GO-polymer composite preparation was used to explain this observation. The linear dependence of Rctversus virus concentrations ranged from 1 to 2 × 103 pfu/mL DENV with a 0.12 pfu/mL detection limit.
ISSN: 15499642
Appears in Collections:Scopus 2016-2017

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