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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/42012
Title: Global and regional dissemination and evolution of Burkholderia pseudomallei
Authors: Claire Chewapreecha
Matthew T.G. Holden
Minna Vehkala
Niko Välimäki
Zhirong Yang
Simon R. Harris
Alison E. Mather
Apichai Tuanyok
Birgit De Smet
Simon Le Hello
Chantal Bizet
Mark Mayo
Vanaporn Wuthiekanun
Direk Limmathurotsakul
Rattanaphone Phetsouvanh
Brian G. Spratt
Jukka Corander
Paul Keim
Gordon Dougan
David A.B. Dance
Bart J. Currie
Julian Parkhill
Sharon J. Peacock
University of Cambridge
Wellcome Trust Sanger Institute
King Mongkut s University of Technology Thonburi
University of St Andrews, School of Medicine
Helsingin Yliopisto
University of Helsinki Faculty of Medicine
University of Florida
Prins Leopold Instituut voor Tropische Geneeskunde
Ghent University, Laboratory of Microbiology
Institut Pasteur, Paris
Menzies School of Health Research
Mahidol University
University of Oxford
Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU)
Imperial College London
Universitetet i Oslo
Northern Arizona University
London School of Hygiene & Tropical Medicine
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 23-Jan-2017
Citation: Nature Microbiology. Vol.2, (2017)
Abstract: © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved. The environmental bacterium Burkholderia pseudomallei causes an estimated 165,000 cases of human melioidosis per year worldwide and is also classified as a biothreat agent. We used whole genome sequences of 469 B. pseudomallei isolates from 30 countries collected over 79 years to explore its geographic transmission. Our data point to Australia as an early reservoir, with transmission to Southeast Asia followed by onward transmission to South Asia and East Asia. Repeated reintroductions were observed within the Malay Peninsula and between countries bordered by the Mekong River. Our data support an African origin of the Central and South American isolates with introduction of B. pseudomallei into the Americas between 1650 and 1850, providing a temporal link with the slave trade. We also identified geographically distinct genes/variants in Australasian or Southeast Asian isolates alone, with virulence-associated genes being among those over-represented. This provides a potential explanation for clinical manifestations of melioidosis that are geographically restricted.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85010282468&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/42012
ISSN: 20585276
Appears in Collections:Scopus 2016-2017

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