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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/42015
Title: A new neolignan, and the cytotoxic and anti-HIV-1 activities of constituents from the roots of Dasymaschalon sootepense
Authors: Sakchai Hongthong
Chutima Kuhakarn
Thaworn Jaipetch
Pawinee Piyachaturawat
Surawat Jariyawat
Kanoknetr Suksen
Jitra Limthongkul
Narong Nuntasaen
Vichai Reutrakul
Mahidol University
Ministry of Natural Resources and Environment
Keywords: Agricultural and Biological Sciences
Issue Date: 1-Jan-2016
Citation: Natural Product Communications. Vol.11, No.6 (2016), 809-813
Abstract: Bioassay-guided isolation from the ethyl acetate extract of Dasymaschalon sootepense roots led to the isolation of twelve compounds including a new dihydrobenzo-furan neolignan, (+)-(2S, 3S)-2, 3-dihydro-2-(3, 4-dimethoxyphenyl)-3-methylbenzofuran-5-carbaldehyde (5), and eleven known compounds (1-4, and 6-12). The chemical structures and stereochemistry of all the isolated compounds were established by spectroscopic techniques. The known compounds 4 and 6 have been fully characterized spectroscopically, including their absolute configurations. Cytotoxic and anti-HIV-1 reverse transcriptase (RT) activities of compounds 1-3, 5 and 8-12 were determined. Among compounds screened, compounds 2, 3 and 10 displayed weak cytotoxic activity with ED50values ranging from 9.6-47.5 μM and only compound 2 was found weakly active against HIV-1 RT with an IC50 value of 323.2 μM.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84989204377&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/42015
ISSN: 15559475
1934578X
Appears in Collections:Scopus 2016-2017

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