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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/42041
Title: Loss of maternal Trim28 causes male-predominant early embryonic lethality
Authors: Abhishek Sampath Kumar
Michelle K.Y. Seah
Ka Yi Ling
Yaju Wang
Joel H.L. Tan
Sandra Nitsch
Shu Ly Lim
Chanchao Lorthongpanich
Heike Wollmann
Diana H.P. Low
Ernesto Guccione
Daniel M. Messerschmidt
A-Star, Institute of Molecular and Cell Biology
Yong Loo Lin School of Medicine
Mahidol University
Agency for Science, Technology and Research, Singapore
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jan-2017
Citation: Genes and Development. Vol.31, No.1 (2017), 12-17
Abstract: © 2017 Kumar et al. Global DNA demethylation is a hallmark of embryonic epigenetic reprogramming. However, embryos engage noncanonical DNA methylation maintenance mechanisms to ensure inheritance of exceptional epigenetic germline features to the soma. Besides the paradigmatic genomic imprints, these exceptions remain ill-defined, and the mechanisms ensuring demethylation resistance in the light of global reprogramming remain poorly understood. Here we show that the Y-linked gene Rbmy1a1 is highly methylated in mature sperm and resists DNA demethylation post-fertilization. Aberrant hypomethylation of the Rbmy1a1 promoter results in its ectopic activation, causing male-specific peri-implantation lethality. Rbmy1a1 is a novel target of the TRIM28 complex, which is required to protect its repressive epigenetic state during embryonic epigenetic reprogramming.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85011615095&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/42041
ISSN: 15495477
08909369
Appears in Collections:Scopus 2016-2017

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