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Title: The case for adopting the "species complex" nomenclature for the etiologic agents of cryptococcosis
Authors: Kyung J. Kwon-Chung
John E. Bennett
Brian L. Wickes
Wieland Meyer
Christina A. Cuomo
Kurt R. Wollenburg
Tihana A. Bicanic
Elizabeth Castañeda
Yun C. Chang
Jianghan Chen
Massimo Cogliati
Françoise Dromer
David Ellis
Scott G. Filler
Matthew C. Fisher
Thomas S. Harrison
Steven M. Holland
Shigeru Kohno
James W. Kronstad
Marcia Lazera
Stuart M. Levitz
Michail S. Lionakis
Robin C. May
Popchai Ngamskulrongroj
Peter G. Pappas
John R. Perfect
Volker Rickerts
Tania C. Sorrell
Thomas J. Walsh
Peter R. Williamson
Jianping Xu
Adrian M. Zelazny
Arturo Casadevall
National Institute of Allergy and Infectious Diseases
University of Texas Health Science Center at San Antonio
The University of Sydney
Westmead Institute for Medical Research
Broad Institute
St George's University of London
Instituto Nacional de Salud
Changzheng Hospital
Università degli Studi di Milano
Institut Pasteur, Paris
The University of Adelaide
Harbor-UCLA Medical Center
Imperial College London
Nagasaki University
Michael Smith Laboratories
Fundacao Oswaldo Cruz
University of Massachusetts Medical School
University of Birmingham
Mahidol University
University of Alabama at Birmingham
Duke University School of Medicine
Robert Koch Institut
Weill Cornell Medicine
McMaster University
Hainan Medical University
National Institutes of Health, Bethesda
The Johns Hopkins School of Medicine
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jan-2017
Citation: mSphere. Vol.2, No.1 (2017)
Abstract: © 2017 Kwon-Chung et al. Cryptococcosis is a potentially lethal disease of humans/animals caused by Cryptococcus neoformans and Cryptococcus gattii. Distinction between the two species is based on phenotypic and genotypic characteristics. Recently, it was proposed that C. neoformans be divided into two species and C. gattii into five species based on a phylogenetic analysis of 115 isolates. While this proposal adds to the knowledge about the genetic diversity and population structure of cryptococcosis agents, the published genotypes of 2,606 strains have already revealed more genetic diversity than is encompassed by seven species. Naming every clade as a separate species at this juncture will lead to continuing nomenclatural instability. In the absence of biological differences between clades and no consensus about how DNA sequence alone can delineate a species, we recommend using "Cryptococcus neoformans species complex" and "C. gattii species complex" as a practical intermediate step, rather than creating more species. This strategy recognizes genetic diversity without creating confusion.
ISSN: 23795042
Appears in Collections:Scopus 2016-2017

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