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Title: Dapsone-induced severe cutaneous adverse drug reactions are strongly linked with HLA-B ∗ 13:01 allele in the Thai population
Authors: Therdpong Tempark
Patompong Satapornpong
Pawinee Rerknimitr
Nontaya Nakkam
Niwat Saksit
Penpun Wattanakrai
Thawinee Jantararoungtong
Napatrupron Koomdee
Ajanee Mahakkanukrauh
Wichittra Tassaneeyakul
Sumitra Suttisai
Jirawat Pratoomwun
Jettanong Klaewsongkram
Ticha Rerkpattanapipat
Chonlaphat Sukasem
Chulalongkorn University
Mahidol University
Thai Severe Cutaneous Adverse Drug Reaction (Thai-SCAR) Research Group
Khon Kaen University
University of Phayao
Phrae Hospital
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jan-2017
Citation: Pharmacogenetics and Genomics. Vol.27, No.12 (2017), 429-437
Abstract: © 2017 Wolters Kluwer Health, Inc. All rights reserved. Objectives A previous publication in Chinese leprosy patients showed that the HLA-B∗13:01 allele is a strong genetic marker for dapsone-induced drug hypersensitivity reactions, however there are no data describing whether HLA-B∗13:01 is a valid marker for prediction of dapsone-induced drug hypersensitivity reactions in other ethnicities or nonleprosy patients. The aim of this study is to investigate whether there is an association between HLA genotypes and dapsone-induced severe cutaneous adverse reactions (SCARs) in Thai nonleprosy patients. Patients and methods HLA-B genotypes of 15 patients with dapsone-induced SCARs (11 drug reaction with eosinophilia and systemic symptoms, 4 Stevens-Johnson syndrome/toxic epidermal necrolysis), 29 control patients, and 986 subjects from the general Thai population were determined by the reverse PCR sequence-specific oligonucleotides probe. Results The HLA-B∗13:01 allele was significantly associated with dapsone-induced SCARs compared with dapsone-tolerant controls (odds ratio: 54.00, 95% confidence interval: 7.96-366.16, P=0.0001) and the general population (odds ratio: 26.11, 95% confidence interval: 7.27-93.75, P=0.0001). In addition, HLA-B∗13:01 associated with dapsone-induced SJS-TEN (OR: 40.50, 95% confidence interval: 2.78-591.01, P=0.0070) and DRESS (OR: 60.75, 95% confidence interval: 7.44-496.18, P=0.0001). Conclusion This study demonstrated an association between HLA-B∗13:01 and dapsone-induced SCARs including Stevens-Johnson syndrome/toxic epidermal necrolysis and drug reaction with eosinophilia and systemic symptoms in nonleprosy patients. Moreover, these results suggest that the HLA-B∗13:01 allele may be a useful genetic marker for prediction of dapsone-induced SCARs in Thai and Han-Chinese populations.
ISSN: 17446880
Appears in Collections:Scopus 2016-2017

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