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Title: Patients with uninjured lungs may also benefit from lung-protective ventilator settings
Authors: Ary Serpa Neto
Roger Alencar
Vittorio D'Angelo
Rachel Carmona
Marcus J. Schultz
Hospital Israelita Albert Einstein
Academic Medical Centre, University of Amsterdam
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jan-2017
Citation: F1000Research. Vol.6, (2017)
Abstract: © 2017 Alencar R et al. Although mechanical ventilation is a life-saving strategy in critically ill patients and an indispensable tool in patients under general anesthesia for surgery, it also acts as a double-edged sword. Indeed, ventilation is increasingly recognized as a potentially dangerous intrusion that has the potential to harm lungs, in a condition known as 'ventilator-induced lung injury' (VILI). So-called 'lung-protective' ventilator settings aiming at prevention of VILI have been shown to improve outcomes in patients with acute respiratory distress syndrome (ARDS), and, over the last few years, there has been increasing interest in possible benefit of lung-protective ventilation in patients under ventilation for reasons other than ARDS. Patients without ARDS could benefit from tidal volume reduction during mechanical ventilation. However, it is uncertain whether higher levels of positive end-expiratory pressure could benefit these patients as well. Finally, recent evidence suggests that patients without ARDS should receive low driving pressures during ventilation.
ISSN: 1759796X
Appears in Collections:Scopus 2016-2017

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