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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/42100
Title: Dried blood spot thyroglobulin as a biomarker of iodine status in pregnant women
Authors: Sara Stinca
Maria Andersson
Sandra Weibel
Isabelle Herter-Aeberli
Ralph Fingerhut
Sueppong Gowachirapant
Sonja Y. Hess
Nidhi Jaiswal
Tomislav Jukić
Zvonko Kusic
Ngoako Solomon Mabapa
Ashwini Kumar Nepal
Teofilo O.L. San Luis
Jia Qing Zhen
Michael Bruce Zimmermann
ETH Zurich
Kinderspital Zürich
Mahidol University
University of California, Davis
St. John's National Academy Of Health Sciences India
University of Zagreb School of Medicine
University of Venda for Science and Technology
B P Koirala Institute of Health Sciences
Iodine Global Network (IGN)
Shanxi Institute for Endemic Disease Prevention and Treatment
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jan-2017
Citation: Journal of Clinical Endocrinology and Metabolism. Vol.102, No.1 (2017), 23-32
Abstract: © 2017 by the Endocrine Society. Context: Thyroglobulin (Tg) could be a sensitive biomarker of iodine nutrition in pregnant women (PW). A dried blood spot (DBS) assay would simplify collection and transport in field studies. Objectives: Our aims were to (1) establish and test a reference range for DBS-Tg in PW; (2) determine whether co-measurement of Tg antibodies (Abs) is necessary to define population iodine status. Design, Setting, and Participants: Standardized cross-sectional studies of 3870 PW from 11 countries. For the DBS-Tg reference range, we included TgAb-negative PW (n = 599) from 3 countries with sufficient iodine intake. Main Outcome Measures: We measured the urinary iodine concentration and DBS thyroidstimulating hormone, total thyroxin, Tg, and TgAb. Results: In the reference population, the median DBS-Tg was 9.2 μg/L (95% confidence interval, 8.7 to 9.8 mg/L) and was not significantly different among trimesters. The reference range was 0.3 to 43.5 mg/L. Over a range of iodine intake, the Tg concentrations were U-shaped. Within countries, the median DBS-Tg and the presence of elevated DBS-Tg did not differ significantly between all PW and PW who were TgAb-negative. Conclusions: A median DBS-Tg of ∼10 mg/L with ,3% of values ≥44 μg/L indicated population iodine sufficiency. Concurrent measurement of TgAb did not appear necessary to assess the population iodine status.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85010617560&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/42100
ISSN: 19457197
0021972X
Appears in Collections:Scopus 2016-2017

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