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Title: Synthesis of synthetic mannan backbone polysaccharides found on the surface of Mycobacterium tuberculosis as a vaccine adjuvant and their immunological properties
Authors: Chakree Wattanasiri
Jiraporn Paha
Marisa Ponpuak
Somsak Ruchirawat
Siwarutt Boonyarattanakalin
Center of Excellence on Environmental Health
Mahidol University
Chulabhorn Research Institute
Sirindhorn International Institute of Technology, Thammasat University
Keywords: Chemistry
Issue Date: 1-Nov-2017
Citation: Carbohydrate Polymers. Vol.175, (2017), 746-755
Abstract: © 2017 Elsevier Ltd Surface components of Mycobacterium tuberculosis (Mtb) play crucial roles in modulating host immune responses. Thorough understandings of immunological properties of the Mtb's surface components are essential for the development of tuberculosis treatment and prevention. Unfortunately, the accessibility to the molecules on the surface of Mtb is limited by the structural complexity due to their various macromolecular nature and the hazard of culturing Mtb. In this study, we reveal a practical synthesis of lipomannan (LM) backbone polysaccharides – the core glycans found on Mtb's surface. A rapid synthetic approach based on a controlled polymerization was developed for the chemical synthesis of mannopyranans, the core structure of LM. The size of the LM glycans can be controlled by using specific monomer concentrations in addition to stereo- and regioselectivity derived from the versatile tricyclic orthoester mannose monomer. The immunological properties of the synthesized mannopyranans were investigated and their adjuvant potential was revealed. The adjuvanticity mechanism of the synthetic mannopyranans appears to involve the NF-κB and inflammasome pathways.
ISSN: 01448617
Appears in Collections:Scopus 2016-2017

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