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Title: Effect of binary solid lipid matrix of wax and triglyceride on lipid crystallinity, drug-lipid interaction and drug release of ibuprofen-loaded solid lipid nanoparticles (SLN) for dermal delivery
Authors: Thitirat Chantaburanan
Veerawat Teeranachaideekul
Doungdaw Chantasart
Anchalee Jintapattanakit
Varaporn Buraphacheep Junyaprasert
Mahidol University
Keywords: Chemical Engineering
Issue Date: 15-Oct-2017
Citation: Journal of Colloid and Interface Science. Vol.504, (2017), 247-256
Abstract: © 2017 Elsevier Inc. Hypothesis The physicochemical properties of solid lipid nanoparticles (SLN) depend on lipid compositions. An addition of secondary solid complex triglycerides (Softisan 378; S378) into solid wax (cetyl palmitate; CP) is expected to influence the properties of obtained SLN compared to SLN prepared from sole CP. Experiments Ibuprofen-loaded SLN (IBSLN-TG) composed of different ratios of CP and S378 were prepared and evaluated in term of size, zeta potential (ZP), entrapment efficiency (E.E.), crystallinity, lipid-drug interaction and in vitro drug release. Findings After production, all developed IBSLN-TG prepared from different ratios of CP and S378 had the particle size in the nanometer range (180–200 nm) with the ZP values of higher than |−40 mV| and possessed approximately 100% E.E. The release of IBSLN-TG demonstrated the biphasic pattern with a fast release followed by sustained release, which was fitted to Higuchi's kinetics. The addition of S378 into CP-matrix led to a slight decrease in particle size and surface charge, and distortion of CP crystallization. The results from1H-NMR indicated the formation of tiny liquid S378 nanocompartments within CP-matrix. The localization of ibuprofen in the S378 nanocompartments and the interaction between ibuprofen and S378 had an impact on the release profiles of IBSLN-TG depending on the ratios of CP and S378.
ISSN: 10957103
Appears in Collections:Scopus 2016-2017

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