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Title: Brompheniramine as a novel probe for indirect UV detection and its application for the capillary electrophoresis of adamantane drugs
Authors: Pornpan Prapatpong
Brompoj Prutthiwanasan
Nantana Nuchtavorn
Sawanya Buranaphalin
Leena Suntornsuk
Mahidol University
Keywords: Chemical Engineering;Chemistry
Issue Date: 1-Mar-2017
Citation: Journal of Separation Science. Vol.40, No.5 (2017), 1184-1192
Abstract: © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Brompheniramine, an antihistamine drug, was employed as a novel UV probe for capillary electrophoresis with indirect UV detection of adamantane drugs (memantine, amantadine, and rimantadine). The probe possesses high molar absorptivity of 24 × 103L/mol cm at 6 mM, which enables the measurement of these nonchromophore analytes without derivatization. The simple background electrolyte (10 mM sodium dihydrogen phosphate (pH 5.0) containing 5 mM brompheniramine and 6 mM β-cyclodextrin) provided the separation of the analytes in a short time (7.5 min). Under these conditions, brompheniramine had similar mobility to that of the analyte ions resulting in symmetric peaks with minimal electrodispersion. The analytes displace the probe at a one-to-one ratio with transfer values close to unity. β-Cyclodextrin played a role in the resolution of the structurally similar adamantane derivatives. Method validation showed good linearity (r2 > 0.98), precision (%RSD ≤ 3.30), and accuracy (recoveries ranging from 98 to 109%). The proposed method was successfully applied to determine the adamantane content in pharmaceutical products.
ISSN: 16159314
Appears in Collections:Scopus 2016-2017

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