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Title: Enhanced degradation of chitosan by applying plasma treatment in combination with oxidizing agents for potential use as an anticancer agent
Authors: Chayanaphat Chokradjaroen
Ratana Rujiravanit
Anyarat Watthanaphanit
Sewan Theeramunkong
Nagahiro Saito
Kazuko Yamashita
Ryuichi Arakawa
Chulalongkorn University
Mahidol University
Thammasat University
Nagoya University
Kansai University
Keywords: Chemistry
Issue Date: 1-Jul-2017
Citation: Carbohydrate Polymers. Vol.167, (2017), 1-11
Abstract: © 2017 Elsevier Ltd Solution plasma (SP) treatment in combination with oxidizing agents, i.e., hydrogen peroxide (H2O2), potassium persulfate (K2S2O8) and sodium nitrite (NaNO2) were adopted to chitosan degradation in order to achieve fast degradation rate, low chemicals used and high yield of low-molecular-weight chitosan and chitooligosaccharide (COS). Among the studied oxidizing agents, H2O2 was found to be the best choice in terms of appreciable molecular weight reduction without major change in chemical structure of the degraded products of chitosan. By the combination with SP treatment, dilute solution of H2O2 (4–60 mM) was required for effective degradation of chitosan. The combination of SP treatment and dilute solution of H2O2 (60 mM) resulted in the great reduction of molecular weight of chitosan and water-soluble chitosan was obtained as a major product. The resulting water-soluble chitosan was precipitated to obtain COS. An inhibitory effect against cervical cancer cell line (HeLa cells) of COS was also examined.
ISSN: 01448617
Appears in Collections:Scopus 2016-2017

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