Simple jQuery Dropdowns
Please use this identifier to cite or link to this item:
Title: Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors
Authors: Jonathon Torchia
Brian Golbourn
Shengrui Feng
King Ching Ho
Patrick Sin-Chan
Alexandre Vasiljevic
Joseph D. Norman
Paul Guilhamon
Livia Garzia
Natalia R. Agamez
Mei Lu
Tiffany S. Chan
Daniel Picard
Pasqualino de Antonellis
Dong Anh Khuong-Quang
Aline C. Planello
Constanze Zeller
Dalia Barsyte-Lovejoy
Lucie Lafay-Cousin
Louis Letourneau
Mathieu Bourgey
Man Yu
Deena M.A. Gendoo
Misko Dzamba
Mark Barszczyk
Tiago Medina
Alexandra N. Riemenschneider
A. Sorana Morrissy
Young Shin Ra
Vijay Ramaswamy
Marc Remke
Christopher P. Dunham
Stephen Yip
Ho keung Ng
Jian Qiang Lu
Vivek Mehta
Steffen Albrecht
Jose Pimentel
Jennifer A. Chan
Gino R. Somers
Claudia C. Faria
Lucia Roque
Maryam Fouladi
Lindsey M. Hoffman
Andrew S. Moore
Yin Wang
Seung Ah Choi
Jordan R. Hansford
Daniel Catchpoole
Diane K. Birks
Nicholas K. Foreman
Doug Strother
Almos Klekner
Laszló Bognár
Miklós Garami
Péter Hauser
Tibor Hortobágyi
Beverly Wilson
Juliette Hukin
Anne Sophie Carret
Timothy E. Van Meter
Eugene I. Hwang
Amar Gajjar
Shih Hwa Chiou
Hideo Nakamura
Helen Toledano
Iris Fried
Daniel Fults
Takafumi Wataya
Chris Fryer
David D. Eisenstat
Katrin Scheinemann
Adam J. Fleming
Donna L. Johnston
Jean Michaud
University of Toronto
Hospital for Sick Children University of Toronto
Ontario Cancer Institute University of Toronto
CHU de Lyon
McGill University
Alberta Children's Hospital
University of Calgary
Asan Medical Center
The University of British Columbia
Chinese University of Hong Kong
University of Alberta
Santa Maria Hospital, Lisbon
Instituto Portugues de Oncologia de Francisco Gentil Lisboa
Cincinnati Children's Hospital Medical Center
University of Colorado School of Medicine
University of Queensland
Fudan University
Seoul National University College of Medicine
Royal Children's Hospital, Melbourne
Children's Hospital At Westmead
Debreceni Egyetem Altalanos Orvostudomanyi Kar
Semmelweis Egyetem
Szegedi Tudomanyegyetem (SZTE)
University of Montreal
Virginia Commonwealth University
Childrens National Health System
St. Jude Children's Research Hospital
National Yang-Ming University Taiwan
Kumamoto University
Children's Medical Center of Israel
Hadassah University Medical Centre
University of Utah, School of Medicine
Shizuoka Children's Hospital
McMaster University, Faculty of Health Sciences
Children's Hospital of Eastern Ontario, Ottawa
London Health Sciences Centre
Western University
Dalhousie University
Mahidol University
University of Nottingham
Ann & Robert H. Lurie Children's Hospital of Chicago
University of California, San Francisco
University of Alabama
Julius-Maximilians-Universität Würzburg
Keywords: Biochemistry, Genetics and Molecular Biology;Medicine
Issue Date: 12-Dec-2016
Citation: Cancer Cell. Vol.30, No.6 (2016), 891-908
Abstract: © 2016 Elsevier Inc. We recently reported that atypical teratoid rhabdoid tumors (ATRTs) comprise at least two transcriptional subtypes with different clinical outcomes; however, the mechanisms underlying therapeutic heterogeneity remained unclear. In this study, we analyzed 191 primary ATRTs and 10 ATRT cell lines to define the genomic and epigenomic landscape of ATRTs and identify subgroup-specific therapeutic targets. We found ATRTs segregated into three epigenetic subgroups with distinct genomic profiles, SMARCB1 genotypes, and chromatin landscape that correlated with differential cellular responses to a panel of signaling and epigenetic inhibitors. Significantly, we discovered that differential methylation of a PDGFRB-associated enhancer confers specific sensitivity of group 2 ATRT cells to dasatinib and nilotinib, and suggest that these are promising therapies for this highly lethal ATRT subtype.
ISSN: 18783686
Appears in Collections:Scopus 2016-2017

Files in This Item:
There are no files associated with this item.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.