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dc.contributor.authorPakin Sukampornen_US
dc.contributor.authorSeung Joon Baeken_US
dc.contributor.authorWandee Gritsanapanen_US
dc.contributor.authorSuwabun Chirachanchaien_US
dc.contributor.authorThararat Nualsaniten_US
dc.contributor.authorPleumchitt Rojanapanthuen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherSeoul National Universityen_US
dc.contributor.otherPhyto Product Researchen_US
dc.contributor.otherChulalongkorn Universityen_US
dc.contributor.otherThammasat Universityen_US
dc.identifier.citationMaterials Science and Engineering C. Vol.77, (2017), 1068-1077en_US
dc.description.abstract© 2017 Damnacanthal (Dam) is a phytochemical with many pharmacological properties including anticancer activity. However, its hydrophobicity, poor bioavailability and stability limit its application in many biological approaches. In this study, Dam nanomicelles as an emerging platform were developed to overcome limitations. The deoxycholic and poly(ethylene glycol) methyl ether grafted chitosan (DCA-CS-mPEG) was synthesized and characterized by FTIR and 1H NMR and the degree of substitution (DS) was determined by elemental analysis (EA). This polymer formed self-assembled micelles with a core-shell structure and a critical micelle concentration (CMC) of 37.2 μg/mL. Dam-loaded polymeric micelles were prepared by dialysis method and characterized by DLS, TEM, FTIR, DSC and HPLC. The mean particle size of Dam-loaded micelles was about 200 nm with spherical shape. The drug entrapment efficiency was up to 57.7%. FTIR and DSC analysis revealed that Dam was entrapped in the micelles in the amorphous state. The in vitro release profiles of Dam from micelles were sustained release and pH-sensitive behavior. Cytotoxic studies exhibited the comparable efficacy and safety of this delivery system. Overall these results indicate the possible utilization of DCA-CS-mPEG micelles as a promising carrier for hydrophobic compounds like Dam.en_US
dc.rightsMahidol Universityen_US
dc.titleSelf-assembled nanomicelles of damnacanthal-loaded amphiphilic modified chitosan: Preparation, characterization and cytotoxicity studyen_US
Appears in Collections:Scopus 2016-2017

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