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Title: Bridging the gap between clinicians and systems biologists: From network biology to translational biomedical research
Authors: Natini Jinawath
Sacarin Bunbanjerdsuk
Maneerat Chayanupatkul
Nuttapong Ngamphaiboon
Nithi Asavapanumas
Jisnuson Svasti
Varodom Charoensawan
Mahidol University
Chulalongkorn University
Baylor College of Medicine
Chulabhorn Research Institute
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 22-Nov-2016
Citation: Journal of Translational Medicine. Vol.14, No.1 (2016)
Abstract: © 2016 The Author(s). With the wealth of data accumulated from completely sequenced genomes and other high-throughput experiments, global studies of biological systems, by simultaneously investigating multiple biological entities (e.g. genes, transcripts, proteins), has become a routine. Network representation is frequently used to capture the presence of these molecules as well as their relationship. Network biology has been widely used in molecular biology and genetics, where several network properties have been shown to be functionally important. Here, we discuss how such methodology can be useful to translational biomedical research, where scientists traditionally focus on one or a small set of genes, diseases, and drug candidates at any one time. We first give an overview of network representation frequently used in biology: what nodes and edges represent, and review its application in preclinical research to date. Using cancer as an example, we review how network biology can facilitate system-wide approaches to identify targeted small molecule inhibitors. These types of inhibitors have the potential to be more specific, resulting in high efficacy treatments with less side effects, compared to the conventional treatments such as chemotherapy. Global analysis may provide better insight into the overall picture of human diseases, as well as identify previously overlooked problems, leading to rapid advances in medicine. From the clinicians' point of view, it is necessary to bridge the gap between theoretical network biology and practical biomedical research, in order to improve the diagnosis, prevention, and treatment of the world's major diseases.
ISSN: 14795876
Appears in Collections:Scopus 2016-2017

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