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dc.contributor.authorEstefania Fernandezen_US
dc.contributor.authorWanwisa Dejnirattisaien_US
dc.contributor.authorBin Caoen_US
dc.contributor.authorSuzanne M. Scheafferen_US
dc.contributor.authorPiyada Supasaen_US
dc.contributor.authorWiyada Wongwiwaten_US
dc.contributor.authorPrabagaran Esakkyen_US
dc.contributor.authorAndrea Druryen_US
dc.contributor.authorJuthathip Mongkolsapayaen_US
dc.contributor.authorKelle H. Moleyen_US
dc.contributor.authorIndira U. Mysorekaren_US
dc.contributor.authorGavin R. Screatonen_US
dc.contributor.authorMichael S. Diamonden_US
dc.contributor.otherWashington University School of Medicine in St. Louisen_US
dc.contributor.otherImperial College Londonen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Oxforden_US
dc.identifier.citationNature Immunology. Vol.18, No.11 (2017), 1261-1269en_US
dc.description.abstract© 2017 Nature America, Inc., part of Springer Nature. All rights reserved. The Zika virus (ZIKV) epidemic has resulted in congenital abnormalities in fetuses and neonates. Although some cross-reactive dengue virus (DENV)-specific antibodies can enhance ZIKV infection in mice, those recognizing the DENV E-dimer epitope (EDE) can neutralize ZIKV infection in cell culture. We evaluated the therapeutic activity of human monoclonal antibodies to DENV EDE for their ability to control ZIKV infection in the brains, testes, placentas, and fetuses of mice. A single dose of the EDE1-B10 antibody given 3 d after ZIKV infection protected against lethality, reduced ZIKV levels in brains and testes, and preserved sperm counts. In pregnant mice, wild-type or engineered LALA variants of EDE1-B10, which cannot engage Fcg receptors, diminished ZIKV burden in maternal and fetal tissues, and protected against fetal demise. Because neutralizing antibodies to EDE have therapeutic potential against ZIKV, in addition to their established inhibitory effects against DENV, it may be possible to develop therapies that control disease caused by both viruses.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleHuman antibodies to the dengue virus E-dimer epitope have therapeutic activity against Zika virus infectionen_US
Appears in Collections:Scopus 2016-2017

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