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Title: Mosquito allergy in children: Clinical features and limitation of commercially-available diagnostic tests
Authors: Wiparat Manuyakorn
Sulak Itsaradisaikul
Suwat Benjaponpitak
Wasu Kamchaisatian
Cherapat Sasisakulporn
Wanlapa Jotikasthira
Ponpan Matangkasombut
Mahidol University
Keywords: Immunology and Microbiology
Issue Date: 1-Dec-2017
Citation: Asian Pacific Journal of Allergy and Immunology. Vol.35, No.4 (2017), 186-190
Abstract: © 2017, Allergy and Immunology Society of Thailand. All rights reserved. Objective: To determine the clinical features of mosquito allergy in children and the ability of commercially available mosquito allergy tests to detect children with mosquito allergy in Thailand. Methods: Patients with mosquito allergy aged 1 month to 18 years were recruited. Demographic data, history of mosquito allergy (onset of the reaction, reaction type) and clinical features were recorded. A skin prick test using a commercially available whole body allergen extract from Culex pipiens was performed, and serum was tested for specific IgE antibodies to Aedes communis whole body extract. Results: A total of 50 patients with mosquito allergy were enrolled. The median age of enrolled children was 6.2 years with an average age of onset of 2 years [interquartile range (IQR) 1–6]. Half of the children were female. The most common skin lesion from mosquito allergy was erythematous papules (n = 45, 76.3%). The majority of children (58%) were in stage 3 (immediate and delayed type of reactions). One child (2%) was in the desensitization stage after 4.6 years of symptoms. The causative mosquito species could be identified only in 26 (52%) children: 16 (32%) children were positive for Aedes communis, 17 (34%) children were positive for Culex pipiens and 7 (14%) children were positive for both Aedes communis and Culex pipiens. Having positive IgE antibodies against Aedes communis was significantly more common in boys (n = 13, 48.1%) than girls (n = 3, 13%) (p < 0.01). Conclusion: Immediate and delayed skin reaction is the most common manifestation in mosquito allergy children. Commercially available tests for mosquito allergy can detect only 30–50% of children with mosquito allergy.
ISSN: 22288694
Appears in Collections:Scopus 2016-2017

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