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dc.contributor.authorWang Nguitragoolen_US
dc.contributor.authorIvo Muelleren_US
dc.contributor.authorChalermpon Kumpitaken_US
dc.contributor.authorTeerawat Saeseuen_US
dc.contributor.authorSirasate Bantuchaien_US
dc.contributor.authorRitthideach Yorsaengen_US
dc.contributor.authorSurapon Yimsamranen_US
dc.contributor.authorWanchai Maneeboonyangen_US
dc.contributor.authorPatiwat Sa-Angchaien_US
dc.contributor.authorWutthichai Chaimungkunen_US
dc.contributor.authorPrasert Rukmaneeen_US
dc.contributor.authorSupalarp Puangsa-Arten_US
dc.contributor.authorNipon Thanyavanichen_US
dc.contributor.authorCristian Koepflien_US
dc.contributor.authorIngrid Felgeren_US
dc.contributor.authorJetsumon Sattabongkoten_US
dc.contributor.authorPratap Singhasivanonen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherPopulation Health & Immunity Divisionen_US
dc.contributor.otherUniversity of Melbourneen_US
dc.contributor.otherSwiss Tropical and Public Health Institute (Swiss TPH)en_US
dc.identifier.citationParasites & vectors. Vol.10, No.1 (2017), 512en_US
dc.description.abstractBACKGROUND: Low-density asymptomatic infections of Plasmodium spp. are common in low endemicity areas worldwide, but outside Africa, their contribution to malaria transmission is poorly understood. Community-based studies with highly sensitive molecular diagnostics are needed to quantify the asymptomatic reservoir of Plasmodium falciparum and P. vivax infections in Thai communities.METHODS: A cross-sectional survey of 4309 participants was conducted in three endemic areas in Kanchanaburi and Ratchaburi provinces of Thailand in 2012. The presence of P. falciparum and P. vivax parasites was determined using 18S rRNA qPCR. Gametocytes were also detected by pfs25 / pvs25 qRT-PCRs.RESULTS: A total of 133 individuals were found infected with P. vivax (3.09%), 37 with P. falciparum (0.86%), and 11 with mixed P. vivax/ P. falciparum (0.26%). The clear majority of both P. vivax (91.7%) and P. falciparum (89.8%) infections were not accompanied by any febrile symptoms. Infections with either species were most common in adolescent and adult males. Recent travel to Myanmar was highly associated with P. falciparum (OR = 9.0, P = 0.001) but not P. vivax infections (P = 0.13). A large number of P. vivax (71.5%) and P. falciparum (72.0%) infections were gametocyte positive by pvs25/pfs25 qRT-PCR. Detection of gametocyte-specific pvs25 and pfs25 transcripts was strongly dependent on parasite density. pvs25 transcript numbers, a measure of gametocyte density, were also highly correlated with parasite density (r 2 = 0.82, P < 0.001).CONCLUSIONS: Asymptomatic infections with Plasmodium spp. were common in western Thai communities in 2012. The high prevalence of gametocytes indicates that these infections may contribute substantially to the maintenance of local malaria transmission.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleVery high carriage of gametocytes in asymptomatic low-density Plasmodium falciparum and P. vivax infections in western Thailanden_US
Appears in Collections:Scopus 2016-2017

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