Simple jQuery Dropdowns
Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/42729
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSuradej Siripattanapipongen_US
dc.contributor.authorHirotomo Katoen_US
dc.contributor.authorPeerapan Tan-ariyaen_US
dc.contributor.authorMathirut Mungthinen_US
dc.contributor.authorSaovanee Leelayoovaen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherJichi Medical Universityen_US
dc.contributor.otherPhramongkutklao College of Medicineen_US
dc.date.accessioned2018-12-21T07:51:11Z
dc.date.accessioned2019-03-14T08:03:45Z-
dc.date.available2018-12-21T07:51:11Z
dc.date.available2019-03-14T08:03:45Z-
dc.date.issued2017-11-01en_US
dc.identifier.citationJournal of Eukaryotic Microbiology. Vol.64, No.6 (2017), 820-828en_US
dc.identifier.issn15507408en_US
dc.identifier.issn10665234en_US
dc.identifier.other2-s2.0-85018327623en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85018327623&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/42729-
dc.description.abstract© 2017 The Author(s) Journal of Eukaryotic Microbiology © 2017 International Society of Protistologists Leishmania martiniquensis, a zoonotic hemoflagellate, is a causative agent of cutaneous (CL) and visceral leishmaniasis (VL) among humans and animals. This organism, first reported in Martinique Island, now has become an emerging infectious agent in Thailand. Symptomatic cases of L. martiniquensis infection among humans have continuously increased. In the meantime, asymptomatic infection of this novel species has seriously created national public health awareness and concern to prevent and control disease transmission. The unsuccessful serological test using the commercial rK39 dipstick based on antigen from Leishmania donovani to detect the antibodies against VL among infected Thai patients has encouraged us to further explore a new sensitive and specific antigenic epitope. In this study, we determined the sequences and expressed recombinant proteins of kinesin 39 (k39), heat shock protein 70 (hsp70), heat shock protein 83 (hsp83), and glycoprotein 63 (gp63) of L. martiniquensis to evaluate the diagnostic efficiency to detect antibodies against L. martiniquensis in patient sera. The preliminary results from western blot analysis have suggested that K39 is the most sensitive recombinant protein to detect L. martiniquensis. Moreover, this recombinant protein reacts with antibodies against L. donovani and Leishmania infantum, making it a promising antigen for further development of a universal rapid diagnostic tool for VL.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85018327623&origin=inwarden_US
dc.subjectImmunology and Microbiologyen_US
dc.titleComparison of Recombinant Proteins of Kinesin 39, Heat Shock Protein 70, Heat Shock Protein 83, and Glycoprotein 63 for Antibody Detection of Leishmania martiniquensis Infectionen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1111/jeu.12415en_US
Appears in Collections:Scopus 2016-2017

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.