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dc.contributor.authorSinjira Somanunten_US
dc.contributor.authorSasawan Chinratanapisiten_US
dc.contributor.authorPunchama Pacharnen_US
dc.contributor.authorNualanong Visitsunthornen_US
dc.contributor.authorOrathai Jirapongsananuruken_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherBhumibol Adulyadej Hospitalen_US
dc.identifier.citationAsian Pacific Journal of Allergy and Immunology. Vol.35, No.3 (2017), 137-143en_US
dc.description.abstract© 2017, Allergy and Immunology Society of Thailand. All rights reserved. Background: Atopic dermatitis (AD) is the first manifestation of Atopic March. The natural history of AD and predictive factors for Atopic March have not been widely studied in Asia. Objective: To study the natural history and associated factors of disease remission and risk of respiratory allergy in Thai children with AD. Method: Medical records of AD patients attending Allergy clinic at Siriraj hospital from 2004-2014 were reviewed. Patients were further followed-up to obtain current symptoms and treatment. Results: One hundred and two AD patients (60.8% female) were followed for 10.2±4.7 years. The median age at diagnosis was 1.5 (0.1-12.0) years. The most common allergen sensitization was Dermatophagoides pteronyssinus and Dermatophagoides farinae. Forty-four percent of patients had complete remission at the median age of 6.3 (2.0-15.0) years. Forty-seven percent of early AD patients (onset <2 years) had concomitant food allergy which egg and cow’s milk were leading causes. The remission rate of AD was higher in early AD than later onset AD (p=0.02). Allergic rhinitis (AR) and asthma were diagnosed in 61.8% and 29.4% of the patients at the median age of 4.6 and 3.8 years, respectively. Early AD and food allergies were significantly associated with early asthma (onset <3years) (OR=10.80, p<0.01 and OR=8.70, p=0.01). Conclusions: Almost half of AD children had complete remission at school age with a better prognosis in early AD. At preschool age, two-thirds and one-third developed AR and asthma, respectively. Early AD and food allergy were risk factors of early asthma.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleThe natural history of atopic dermatitis and its association with atopic marchen_US
Appears in Collections:Scopus 2016-2017

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