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Title: Targeting Netrin-1 in glioblastoma stem-like cells inhibits growth, invasion, and angiogenesis
Authors: Tanwarat Sanvoranart
Aungkura Supokawej
Pakpoom Kheolamai
Yaowalak U-pratya
Niphon Poungvarin
Sith Sathornsumetee
Surapol Issaragrisil
Mahidol University
Faculty of Medicine, Thammasat University
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Nov-2016
Citation: Tumor Biology. Vol.37, No.11 (2016), 14949-14960
Abstract: © 2016, International Society of Oncology and BioMarkers (ISOBM). Glioblastoma (GBM) is an aggressive malignant brain tumor that still lacks effective therapy. Glioblastoma stem cells (GBM-SCs) were identified to contribute to aggressive phenotypes and poor clinical outcomes for GBM. Netrin-1, an axon guidance molecule, has been found in several tumors in adults. However, the role of Netrin-1 in GBM-SCs remains largely unknown. In this study, CD133-positive U251 GBM cells were used as a putative GBM-SC population to identify the functions of Netrin-1. Using lentiviral transduction, Netrin-1 miR RNAi vectors were transduced into CD133-positive U251 cells. We demonstrated that cell proliferation and survival were decreased following targeted deletion of Netrin-1. Cell invasion was dramatically diminished in Netrin-1 knockdown GBM-SCs. Moreover, Netrin-1 knockdown GBM-SCs exhibited less proangiogenic activity. In conclusion, Netrin-1 may represent a therapeutic target in glioblastoma.
ISSN: 14230380
Appears in Collections:Scopus 2016-2017

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