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dc.contributor.authorTanwarat Sanvoranarten_US
dc.contributor.authorAungkura Supokawejen_US
dc.contributor.authorPakpoom Kheolamaien_US
dc.contributor.authorYaowalak U-pratyaen_US
dc.contributor.authorNiphon Poungvarinen_US
dc.contributor.authorSith Sathornsumeteeen_US
dc.contributor.authorSurapol Issaragrisilen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherFaculty of Medicine, Thammasat Universityen_US
dc.date.accessioned2018-12-11T02:06:57Z
dc.date.accessioned2019-03-14T08:03:48Z-
dc.date.available2018-12-11T02:06:57Z
dc.date.available2019-03-14T08:03:48Z-
dc.date.issued2016-11-01en_US
dc.identifier.citationTumor Biology. Vol.37, No.11 (2016), 14949-14960en_US
dc.identifier.issn14230380en_US
dc.identifier.issn10104283en_US
dc.identifier.other2-s2.0-84988632754en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84988632754&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/42769-
dc.description.abstract© 2016, International Society of Oncology and BioMarkers (ISOBM). Glioblastoma (GBM) is an aggressive malignant brain tumor that still lacks effective therapy. Glioblastoma stem cells (GBM-SCs) were identified to contribute to aggressive phenotypes and poor clinical outcomes for GBM. Netrin-1, an axon guidance molecule, has been found in several tumors in adults. However, the role of Netrin-1 in GBM-SCs remains largely unknown. In this study, CD133-positive U251 GBM cells were used as a putative GBM-SC population to identify the functions of Netrin-1. Using lentiviral transduction, Netrin-1 miR RNAi vectors were transduced into CD133-positive U251 cells. We demonstrated that cell proliferation and survival were decreased following targeted deletion of Netrin-1. Cell invasion was dramatically diminished in Netrin-1 knockdown GBM-SCs. Moreover, Netrin-1 knockdown GBM-SCs exhibited less proangiogenic activity. In conclusion, Netrin-1 may represent a therapeutic target in glioblastoma.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84988632754&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleTargeting Netrin-1 in glioblastoma stem-like cells inhibits growth, invasion, and angiogenesisen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1007/s13277-016-5314-5en_US
Appears in Collections:Scopus 2016-2017

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