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Title: Asymptomatic and sub-microscopic malaria infection in Kayah State, eastern Myanmar
Authors: Myo Thiha Zaw
Myo Thant
Tin Maung Hlaing
Naing Zin Aung
Min Thu
Kanit Phumchuea
Kanokwan Phusri
Teerawat Saeseu
Ritthideach Yorsaeng
Wang Nguitragool
Ingrid Felger
Jaranit Kaewkungwal
Liwang Cui
Jetsumon Sattabongkot
Defence Services Medical Research Centre (DSMRC)
Loikaw Military Hospital
Mahidol University
Swiss Tropical and Public Health Institute (Swiss TPH)
Pennsylvania State University
Keywords: Immunology and Microbiology
Issue Date: 4-Apr-2017
Citation: Malaria Journal. Vol.16, No.1 (2017)
Abstract: © 2017 The Author(s). Background: Myanmar has the heaviest burden of malaria in the Greater Mekong Sub-region. Asymptomatic Plasmodium spp. infections are common in this region and may represent an important reservoir of transmission that must be targeted for malaria elimination. Methods: A mass blood survey was conducted among 485 individuals from six villages in Kayah State, an area of endemic but low transmission malaria in eastern Myanmar. Malaria infection was screened by rapid diagnostic test (RDT), light microscopy and real-time polymerase chain reaction (PCR), and its association with demographic factors was explored. Results: The prevalence of asymptomatic Plasmodium spp. infection was 2.3% (11/485) by real-time PCR. Plasmodium vivax accounted for 72.7% (8/11) and Plasmodium falciparum for 27.3% (3/11) of infections. Men were at greater risk of infection by Plasmodium spp. than women. Individuals who worked as farmers or wood and bamboo cutters had an increased risk of infection. Conclusion: A combination of RDT, light microscopy and PCR diagnostics were used to identify asymptomatic malaria infection, providing additional information on asymptomatic cases in addition to the routine statistics on symptomatic cases, so as to determine the true burden of disease in the area. Such information and risk factors can improve malaria risk stratification and guide decision-makers towards better design and delivery of targeted interventions in small villages, representative of Kayah State.
ISSN: 14752875
Appears in Collections:Scopus 2016-2017

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