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Title: Association between Opisthorchis viverrini and Leptospira spp. infection in endemic Northeast Thailand
Authors: Chinh Dang Van
Galayanee Doungchawee
Sutas Suttiprapa
Yuji Arimatsu
Sasithorn Kaewkes
Banchob Sripa
Khon Kaen University
Hanoi School of Public Health
Mahidol University
Keywords: Immunology and Microbiology
Issue Date: 1-Aug-2017
Citation: Parasitology International. Vol.66, No.4 (2017), 503-509
Abstract: © 2016 Elsevier Ireland Ltd Opisthorchiasis caused by Opisthorchis viverrini is an important foodborne trematodiasis in Thailand, Laos and Cambodia. Interestingly, the opisthorchiasis endemic region overlaps with an area of leptospirosis emergence. Here we report an association between opisthorchiasis and leptospirosis in Thailand. Of 280 sera collected from villagers living around the Lawa wetland complex in Khon Kaen province, 199 (71%) were seropositive for leptospirosis by immunochromatography. Individuals with O. viverrini infection had a significantly higher rate of leptospirosis than those without (P = 0.001). Significant higher leptospirosis prevalence was found in males than females (P = 0.002). However, females but not males with O. viverrini infection showed a significantly higher seroprevalence of leptospirosis. Twenty-one of 35 environmental samples from the lake (water, mud and fish skin mucus) were positive for Leptospira spp. DNA sequencing, sequence alignment, and phylogenetic analysis of some positive nested PCR products revealed both pathogenic and intermediate pathogenic strains of Leptospira in the samples. Strikingly, O. viverrini metacercariae from the fish were positive for L. interrogans. These results suggest a close association between opisthorchiasis and leptospirosis. Contact with water, mud or eating raw fish harboring liver fluke metacercariae may be risk factors for Leptospira infection.
ISSN: 18730329
Appears in Collections:Scopus 2016-2017

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