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dc.contributor.authorChinh Dang Vanen_US
dc.contributor.authorGalayanee Doungchaweeen_US
dc.contributor.authorSutas Suttiprapaen_US
dc.contributor.authorYuji Arimatsuen_US
dc.contributor.authorSasithorn Kaewkesen_US
dc.contributor.authorBanchob Sripaen_US
dc.contributor.otherKhon Kaen Universityen_US
dc.contributor.otherHanoi School of Public Healthen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationParasitology International. Vol.66, No.4 (2017), 503-509en_US
dc.description.abstract© 2016 Elsevier Ireland Ltd Opisthorchiasis caused by Opisthorchis viverrini is an important foodborne trematodiasis in Thailand, Laos and Cambodia. Interestingly, the opisthorchiasis endemic region overlaps with an area of leptospirosis emergence. Here we report an association between opisthorchiasis and leptospirosis in Thailand. Of 280 sera collected from villagers living around the Lawa wetland complex in Khon Kaen province, 199 (71%) were seropositive for leptospirosis by immunochromatography. Individuals with O. viverrini infection had a significantly higher rate of leptospirosis than those without (P = 0.001). Significant higher leptospirosis prevalence was found in males than females (P = 0.002). However, females but not males with O. viverrini infection showed a significantly higher seroprevalence of leptospirosis. Twenty-one of 35 environmental samples from the lake (water, mud and fish skin mucus) were positive for Leptospira spp. DNA sequencing, sequence alignment, and phylogenetic analysis of some positive nested PCR products revealed both pathogenic and intermediate pathogenic strains of Leptospira in the samples. Strikingly, O. viverrini metacercariae from the fish were positive for L. interrogans. These results suggest a close association between opisthorchiasis and leptospirosis. Contact with water, mud or eating raw fish harboring liver fluke metacercariae may be risk factors for Leptospira infection.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleAssociation between Opisthorchis viverrini and Leptospira spp. infection in endemic Northeast Thailanden_US
Appears in Collections:Scopus 2016-2017

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