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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/42806
Title: Artesunate-tafenoquine combination therapy promotes clearance and abrogates transmission of the avian malaria parasite Plasmodium gallinaceum
Authors: Suchada Tasai
Tawee Saiwichai
Morakot Kaewthamasorn
Sonthaya Tiawsirisup
Prayute Buddhirakkul
Sirintip Chaichalotornkul
Sittiporn Pattaradilokrat
Mahidol University
Chulalongkorn University
Mae Fah Luang University
Keywords: Immunology and Microbiology
Issue Date: 15-Jan-2017
Citation: Veterinary Parasitology. Vol.233, (2017), 97-106
Abstract: © 2016 Elsevier B.V. Clinical manifestations of malaria infection in vertebrate hosts arise from the multiplication of the asexual stage parasites in the blood, while the gametocytes are responsible for the transmission of the disease. Antimalarial drugs that target the blood stage parasites and transmissible gametocytes are rare, but are essentially needed for the effective control of malaria and for limiting the spread of resistance. Artemisinin and its derivatives are the current first-line antimalarials that are effective against the blood stage parasites and gametocytes, but resistance to artemisinin has now emerged and spread in various malaria endemic areas. Therefore, a novel antimalarial drug, or a new drug combination, is critically needed to overcome this problem. The objectives of this study were to evaluate the efficacy of a relatively new antimalarial compound, tafenoquine (TQ), and a combination of TQ and a low dose of artesunate (ATN) on the in vivo blood stage multiplication, gametocyte development and transmission of the avian malaria parasite Plasmodium gallinaceum to the vector Aedes aegypti. The results showed that a 5-d treatment with TQ alone was unable to clear the blood stage parasites, but was capable of reducing the mortality rate, while TQ monotherapy at a high dose of 30 mg/kg was highly effective against the gametocytes and completely blocked the transmission of P. gallinaceum. In addition, the combination therapy of TQ + ATN completely cleared P. gallinaceum blood stages and sped up the gametocyte clearance from chickens, suggesting the synergistic effect of the two drugs. In conclusion, TQ is demonstrated to be effective for limiting avian malaria transmission and may be used in combination with a low dose of ATN for safe and effective treatment.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85006992960&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/42806
ISSN: 18732550
03044017
Appears in Collections:Scopus 2016-2017

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