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dc.contributor.authorRhea J. Longleyen_US
dc.contributor.authorCamila T. Françaen_US
dc.contributor.authorMichael T. Whiteen_US
dc.contributor.authorChalermpon Kumpitaken_US
dc.contributor.authorPatiwat Sa-Angchaien_US
dc.contributor.authorJakub Gruszczyken_US
dc.contributor.authorJessica B. Hostetleren_US
dc.contributor.authorAnjali Yadavaen_US
dc.contributor.authorChristopher L. Kingen_US
dc.contributor.authorRick M. Fairhursten_US
dc.contributor.authorJulian C. Rayneren_US
dc.contributor.authorWai Hong Thamen_US
dc.contributor.authorWang Nguitragoolen_US
dc.contributor.authorJetsumon Sattabongkoten_US
dc.contributor.authorIvo Muelleren_US
dc.contributor.otherWalter and Eliza Hall Institute of Medical Researchen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Melbourneen_US
dc.contributor.otherImperial College Londonen_US
dc.contributor.otherWellcome Trust Sanger Instituteen_US
dc.contributor.otherNational Institute of Allergy and Infectious Diseasesen_US
dc.contributor.otherWalter Reed Army Institute of Researchen_US
dc.contributor.otherCase Western Reserve Universityen_US
dc.contributor.otherInstituto de Salud Global de Barcelonaen_US
dc.contributor.otherInstitut Pasteur, Parisen_US
dc.identifier.citationMalaria Journal. Vol.16, No.1 (2017)en_US
dc.description.abstract© 2017 The Author(s). Background: Thailand is aiming to eliminate malaria by the year 2024. Plasmodium vivax has now become the dominant species causing malaria within the country, and a high proportion of infections are asymptomatic. A better understanding of antibody dynamics to P. vivax antigens in a low-transmission setting, where acquired immune responses are poorly characterized, will be pivotal for developing new strategies for elimination, such as improved surveillance methods and vaccines. The objective of this study was to characterize total IgG antibody levels to 11 key P. vivax proteins in a village of western Thailand. Methods: Plasma samples from 546 volunteers enrolled in a cross-sectional survey conducted in 2012 in Kanchanaburi Province were utilized. Total IgG levels to 11 different proteins known or predicted to be involved in reticulocyte binding or invasion (ARP, GAMA, P41, P12, PVX_081550, and five members of the PvRBP family), as well as the leading pre-erythrocytic vaccine candidate (CSP) were measured using a multiplexed bead-based assay. Associations between IgG levels and infection status, age, and spatial location were explored. Results: Individuals from a low-transmission region of western Thailand reacted to all 11 P. vivax recombinant proteins. Significantly greater IgG levels were observed in the presence of a current P. vivax infection, despite all infected individuals being asymptomatic. IgG levels were also higher in adults (18 years and older) than in children. For most of the proteins, higher IgG levels were observed in individuals living closer to the Myanmar border and further away from local health services. Conclusions: Robust IgG responses were observed to most proteins and IgG levels correlated with surrogates of exposure, suggesting these antigens may serve as potential biomarkers of exposure, immunity, or both.en_US
dc.rightsMahidol Universityen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleAsymptomatic Plasmodium vivax infections induce robust IgG responses to multiple blood-stage proteins in a low-transmission region of western Thailanden_US
Appears in Collections:Scopus 2016-2017

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