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Title: A proteasome inhibitor produced by Burkholderia pseudomallei modulates intracellular growth
Authors: Sariqa Wagley
Muthita Vanaporn
Darawan Rinchai
Laura Conejero
Ganjana Lertmemongkolchai
Gregory J. Bancroft
Richard W. Titball
University of Exeter
Mahidol University
Khon Kaen University
London School of Hygiene & Tropical Medicine
Keywords: Immunology and Microbiology
Issue Date: 1-Jun-2017
Citation: Microbial Pathogenesis. Vol.107, (2017), 175-180
Abstract: © 2017 Elsevier Ltd The NRPS/PKS cluster encodes the enzymes necessary for glidobactin synthesis it is partially conserved in various members of the Burkholderia genus including B. pseudomallei. In this study we have shown that the insertional inactivation or deletion of glbC in this cluster in B. pseudomallei could reduce the ability of the bacterium to survive or grow in murine macrophages or in human neutrophils. Exogenously added proteasome inhibitors were able to chemically complement the mutation. The insertional inactivation or deletion of glbC increased virulence in an acute model of infection in Balb/c or C57BL/6 mice but virulence in a chronic model of infection was similar to that of the wild type. Our findings contrast with the previous finding that inactivation of the glb gene cluster in B. pseudomallei strain 1026b resulted in marked attenuation, and provides evidence of differential roles for some genes in virulence of different strains of B. pseudomallei.
ISSN: 10961208
Appears in Collections:Scopus 2016-2017

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