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dc.contributor.authorPhatchawan Arjinajarnen_US
dc.contributor.authorAnchalee Pongchaidechaen_US
dc.contributor.authorNuttawud Chueakulaen_US
dc.contributor.authorKrit Jaikumkaoen_US
dc.contributor.authorVaranuj Chatsudthipongen_US
dc.contributor.authorSugunya Mahatheeranonten_US
dc.contributor.authorOrranuch Norkaewen_US
dc.contributor.authorNipon Chattipakornen_US
dc.contributor.authorAnusorn Lungkaphinen_US
dc.contributor.otherChiang Mai Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationPhytomedicine. Vol.23, No.14 (2016), 1753-1763en_US
dc.description.abstract© 2016 Elsevier GmbH Purpose This study investigated the protective effects of Riceberry bran extract (RBBE) on renal function, and the function and expression of renal organic anion transporter 3 (Oat3) in gentamicin-induced nephrotoxicity in rats and explored the mechanisms for its protective effects. Material and methods Male Sprague Dawley rats (n = 42) were divided into six groups to receive normal saline, gentamicin (100 mg/kg), co-treatment of gentamicin and RBBE (at dose of 250, 500 and 1000 mg/kg), and RBBE (at dose of 1000 mg/kg) only, for consecutive fifteen days. Renal function, oxidative and antioxidative markers, the function and expression of Oat3 and histological changes in the kidney were evaluated. Results Elevation of BUN, serum creatinine levels and reduction in urine creatinine and creatinine clearance indicated decreased renal function in the gentamicin-treated rats. The decrease of [3H]ES uptake in the renal cortical slices of these rats, reflecting the attenuation of Oat3 transport function that was accompanied by decreased expression of Oat3. Moreover, increased MDA level and reduced superoxide dismutase (SOD) and glutathione (GSH) activities were found in gentamicin-treated rats compared to the control group. These changes were associated with the upregulated PKCα, Nrf-2, Keap 1, NQO-1 and HO-1 expressions in kidneys. RBBE treatment improved the renal function and Oat3 transport function and expression in gentamicin-treated rats. The oxidative status was also restored by RBBE treatment. Conclusion RBBE protects kidney injury by its antioxidant effect, subsequently leading to modulation of the PKC/Nrf2 antioxidant defense pathway.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleRiceberry bran extract prevents renal dysfunction and impaired renal organic anion transporter 3 (Oat3) function by modulating the PKC/Nrf2 pathway in gentamicin-induced nephrotoxicity in ratsen_US
Appears in Collections:Scopus 2016-2017

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