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dc.contributor.authorHisayuki Komakien_US
dc.contributor.authorArisa Ishikawaen_US
dc.contributor.authorNatsuko Ichikawaen_US
dc.contributor.authorAkira Hosoyamaen_US
dc.contributor.authorMoriyuki Hamadaen_US
dc.contributor.authorEnjuro Harunarien_US
dc.contributor.authorTakuya Nihiraen_US
dc.contributor.authorWatanalai Panbangreden_US
dc.contributor.authorYasuhiro Igarashien_US
dc.contributor.otherNational Institute of Technology and Evaluation (NBRC)en_US
dc.contributor.otherToyama Prefectural Universityen_US
dc.contributor.otherOsaka Universityen_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationStandards in Genomic Sciences. Vol.11, No.1 (2016)en_US
dc.description.abstract© 2016 The Author(s). Streptomyces sp. MWW064 (=NBRC 110611) produces an antitumor cyclic depsipeptide rakicidin D. Here, we report the draft genome sequence of this strain together with features of the organism and generation, annotation and analysis of the genome sequence. The 7.9 Mb genome of Streptomyces sp. MWW064 encoded 7,135 putative ORFs, of which 6,044 were assigned with COG categories. The genome harbored at least three type I polyketide synthase (PKS) gene clusters, seven nonribosomal peptide synthetase (NRPS) gene clusters, and four hybrid PKS/NRPS gene clusters, from which a hybrid PKS/NRPS gene cluster responsible for rakicidin synthesis was successfully identified. We propose the biosynthetic pathway based on bioinformatic analysis, and experimentally proved that the pentadienoyl unit in rakicidins is derived from serine and malonate.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleDraft genome sequence of Streptomyces sp. MWW064 for elucidating the rakicidin biosynthetic pathwayen_US
Appears in Collections:Scopus 2016-2017

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