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Title: Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax
Authors: Daniel N. Hupalo
Zunping Luo
Alexandre Melnikov
Patrick L. Sutton
Peter Rogov
Ananias Escalante
Andrés F. Vallejo
Sócrates Herrera
Myriam Arévalo-Herrera
Qi Fan
Ying Wang
Liwang Cui
Carmen M. Lucas
Salomon Durand
Juan F. Sanchez
G. Christian Baldeviano
Andres G. Lescano
Moses Laman
Celine Barnadas
Alyssa Barry
Ivo Mueller
James W. Kazura
Alex Eapen
Deena Kanagaraj
Neena Valecha
Marcelo U. Ferreira
Wanlapa Roobsoong
Wang Nguitragool
Jetsumon Sattabonkot
Dionicia Gamboa
Margaret Kosek
Joseph M. Vinetz
Lilia González-Cerón
Bruce W. Birren
Daniel E. Neafsey
Jane M. Carlton
New York University
Broad Institute
Temple University
Caucaseco Scientific Research Center
Universidad del Valle, Cali
Dalian Institute of Biotechnology
Third Military Medical University
Pennsylvania State University
US Naval Medical Research Unit No. 6
Papua New Guinea Institute of Medical Research
Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Instituto de Salud Global de Barcelona
Case Western Reserve University
National Institute of Malaria Research India
Universidade de Sao Paulo - USP
Mahidol University
Universidad Peruana Cayetano Heredia, Instituto de Medicina Tropical Alexander von Humboldt
Universidad Peruana Cayetano Heredia
Johns Hopkins Bloomberg School of Public Health
University of California, San Diego
National Institute for Public Health
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Aug-2016
Citation: Nature Genetics. Vol.48, No.8 (2016), 953-958
Abstract: © 2016 Nature America, Inc. All rights reserved. Plasmodium vivax is a major public health burden, responsible for the majority of malaria infections outside Africa. We explored the impact of demographic history and selective pressures on the P. vivax genome by sequencing 182 clinical isolates sampled from 11 countries across the globe, using hybrid selection to overcome human DNA contamination. We confirmed previous reports of high genomic diversity in P. vivax relative to the more virulent Plasmodium falciparum species; regional populations of P. vivax exhibited greater diversity than the global P. falciparum population, indicating a large and/or stable population. Signals of natural selection suggest that P. vivax is evolving in response to antimalarial drugs and is adapting to regional differences in the human host and the mosquito vector. These findings underline the variable epidemiology of this parasite species and highlight the breadth of approaches that may be required to eliminate P. vivax globally.
ISSN: 15461718
Appears in Collections:Scopus 2016-2017

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