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Title: Lovastatin Analogues from the Soil-Derived Fungus Aspergillus sclerotiorum PSU-RSPG178
Authors: Patima Phainuphong
Vatcharin Rukachaisirikul
Saowanit Saithong
Souwalak Phongpaichit
Kawitsara Bowornwiriyapan
Chatchai Muanprasat
Chutima Srimaroeng
Acharaporn Duangjai
Jariya Sakayaroj
Prince of Songkla University
Mahidol University
Chiang Mai University
University of Phayao
Thailand National Center for Genetic Engineering and Biotechnology
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry
Issue Date: 24-Jun-2016
Citation: Journal of Natural Products. Vol.79, No.6 (2016), 1500-1507
Abstract: © 2016 The American Chemical Society and American Society of Pharmacognosy. Three new lovastatin analogues (1, 4, and 5) together with four known lovastatin derivatives, namely, lovastatin (2), α,β-dehydrolovastatin (3), α,β-dehydrodihydromonacolin K (6), and α,β-dehydro-4a,5-dihydromonacolin L (7), were isolated from the soil-derived fungus Aspergillus sclerotiorum PSU-RSPG178. Their structures were established using spectroscopic evidence. Compound 5 exhibited the most potent activity against HMG-CoA reductase, with an IC50value of 387 μM. In addition, the present study indicated the direct interaction of compound 5 with HMG-CoA reductase. Compound 5 was considered to be noncytotoxic against noncancerous Vero cells, with an IC50value of 40.0 μM, whereas compound 2 displayed much stronger activity, with an IC50value of 2.2 μM.
ISSN: 15206025
Appears in Collections:Scopus 2016-2017

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