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Title: MAIT cells are activated during human viral infections
Authors: Bonnie Van Wilgenburg
Iris Scherwitzl
Edward C. Hutchinson
Tianqi Leng
Ayako Kurioka
Corinna Kulicke
Catherine De Lara
Suzanne Cole
Sirijitt Vasanawathana
Wannee Limpitikul
Prida Malasit
Duncan Young
Laura Denney
Michael D. Moore
Paolo Fabris
Maria Teresa Giordani
Ye Htun Oo
Stephen M. Laidlaw
Lynn B. Dustin
Ling Pei Ho
Fiona M. Thompson
Narayan Ramamurthy
Juthathip Mongkolsapaya
Christian B. Willberg
Gavin R. Screaton
Paul Klenerman
Eleanor Barnes
Jonathan Ball
Gary Burgess
Graham Cooke
John Dillon
Charles Gore
Graham Foster
Neil Guha
Rachel Halford
Cham Herath
Chris Holmes
Anita Howe
Emma Hudson
William Irving
Salim Khakoo
Diana Koletzki
Natasha Martin
Tamyo Mbisa
Jane McKeating
John McLauchlan
Alec Miners
Andrea Murray
Peter Shaw
Peter Simmonds
Chris Spencer
Paul Targett-Adams
Emma Thomson
Peter Vickerman
Nicole Zitzmann
Nuffield Department of Clinical Medicine
Imperial College London
Sir William Dunn School of Pathology
Khon Kaen Regional Hospital
Songkhla Hospital
Thailand National Center for Genetic Engineering and Biotechnology
Mahidol University
John Radcliffe Hospital
Ospedale San Bortolo
University of Birmingham
Kennedy Institute of Rheumatology
University of Oxford
University of Nottingham
Conatus Pharmaceuticals
University of Dundee College of Medicine, Dentistry and Nursing
Hepatitis C Trust
Queen Mary, University of London
Gilead Sciences Ltd
St. Paul's Hospital
University of Southampton
Janssen Diagnostics
University of California, San Diego
Public Health England
University of Glasgow
London School of Hygiene & Tropical Medicine
Nottingham City Hospital
Merck & Co., Inc.
Wellcome Trust Centre for Human Genetics
Medivir AB
University of Bristol
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry
Issue Date: 23-Jun-2016
Citation: Nature Communications. Vol.7, (2016)
Abstract: Mucosal-associated invariant T (MAIT) cells are abundant in humans and recognize bacterial ligands. Here, we demonstrate that MAIT cells are also activated during human viral infections in vivo. MAIT cells activation was observed during infection with dengue virus, hepatitis C virus and influenza virus. This activation - driving cytokine release and Granzyme B upregulation - is TCR-independent but dependent on IL-18 in synergy with IL-12, IL-15 and/or interferon-α/β. IL-18 levels and MAIT cell activation correlate with disease severity in acute dengue infection. Furthermore, HCV treatment with interferon-α leads to specific MAIT cell activation in vivo in parallel with an enhanced therapeutic response. Moreover, TCR-independent activation of MAIT cells leads to a reduction of HCV replication in vitro mediated by IFN-γ. Together these data demonstrate MAIT cells are activated following viral infections, and suggest a potential role in both host defence and immunopathology.
ISSN: 20411723
Appears in Collections:Scopus 2016-2017

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