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Title: Admixture into and within sub-Saharan Africa
Authors: George B.J. Busby
Gavin Band
Quang Si Le
Muminatou Jallow
Edith Bougama
Valentina D. Mangano
Lucas N. Amenga-Etego
Anthony Enimil
Tobias Apinjoh
Carolyne M. Ndila
Alphaxard Manjurano
Vysaul Nyirongo
Ogobara Doumba
Kirk A. Rockett
Dominic P. Kwiatkowski
Chris C.A. Spencer
Aaron Vanderwal
Abier Elzein
Aceme Nyika
Alieu Mendy
Alistair Miles
Andrea Diss
Angeliki Kerasidou
Angie Green
Anna E. Jeffreys
Bronwyn MacInnis
Catherine Hughes
Catherine Moyes
Christina Hubbart
Cinzia Malangone
Claire Potter
Daniel Mead
David Barnwell
Dushyanth Jyothi
Eleanor Drury
Elilan Somaskantharajah
Eliza Hilton
Ellen Leffler
Gareth Maslen
George Busby
Geraldine M. Clarke
Ioannis Ragoussis
Jacob Almagro Garcia
Jane Rogers
Jantina deVries
Jennifer Shelton
Jiannis Ragoussis
Jim Stalker
Joanne Rodford
John O'Brien
Wellcome Trust Centre for Human Genetics
Wellcome Trust Sanger Institute
Medical Research Council Unit
Royal Victoria Teaching Hospital Gambia
Centre National de Recherche et de Formation sur le Paludisme
Università degli Studi di Roma La Sapienza
Navrongo Health Research Center
Komfo Anokye Teaching Hospital
University of Buea
Wellcome Trust Research Laboratories Nairobi
Kilimanjaro Christian Medical College
London School of Hygiene & Tropical Medicine
University of Malawi College of Medicine
University of Bamako
National Institute for Biological Standards and Control
Wellcome Trust
Bernhard Nocht Institut fur Tropenmedizin Hamburg
University of Maryland, Baltimore
National Institute of Allergy and Infectious Diseases
Foundation for the National Institutes of Health
Institut Pasteur de Dakar
Institut Pasteur, Paris
Medical Research Council Laboratories Gambia
University of Ghana
Kwame Nkrumah University of Science and Technology
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 21-Jun-2016
Citation: eLife. Vol.5, No.JUN2016 (2016)
Abstract: © Busby et al. Similarity between two individuals in the combination of genetic markers along their chromosomes indicates shared ancestry and can be used to identify historical connections between different population groups due to admixture. We use a genome-wide, haplotype-based, analysis to characterise the structure of genetic diversity and gene-flow in a collection of 48 sub-Saharan African groups. We show that coastal populations experienced an influx of Eurasian haplotypes over the last 7000 years, and that Eastern and Southern Niger-Congo speaking groups share ancestry with Central West Africans as a result of recent population expansions. In fact, most sub-Saharan populations share ancestry with groups from outside of their current geographic region as a result of gene-flow within the last 4000 years. Our in-depth analysis provides insight into haplotype sharing across different ethno-linguistic groups and the recent movement of alleles into new environments, both of which are relevant to studies of genetic epidemiology.
ISSN: 2050084X
Appears in Collections:Scopus 2016-2017

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