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dc.contributor.authorChih Ching Yehen_US
dc.contributor.authorWen Chang Wangen_US
dc.contributor.authorChien Sheng Wuen_US
dc.contributor.authorFung Chang Sungen_US
dc.contributor.authorChien Tien Suen_US
dc.contributor.authorYing Hua Shiehen_US
dc.contributor.authorShih Ni Changen_US
dc.contributor.authorFu Hsiung Suen_US
dc.contributor.otherTaipei Medical Universityen_US
dc.contributor.otherChina Medical University Taichungen_US
dc.contributor.otherFar Eastern Memorial Hospital Taiwanen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherChina Medical University Hospital Taichungen_US
dc.contributor.otherFlinders Universityen_US
dc.identifier.citationPLoS ONE. Vol.11, No.8 (2016)en_US
dc.description.abstract© 2016 Yeh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Objective: The association between Sjögren's syndrome (SS) and chronic hepatitis virus infection is inconclusive. Hepatitis B (HBV) and hepatitis C virus (HCV) infections are highly prevalent in Taiwan. We used a population-based case-control study to evaluate the associations between SS and HBV and HCV infections. Materials and Methods: We identified 9,629 SS patients without other concomitant autoimmune diseases and 38,516 sex- and age-matched controls without SS from the Taiwan National Health Insurance claims data between 2000 and 2011. We utilized multivariate logistic regression to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) of the associations between SS and HBV and HCV infections. Sex- and age-specific (<55 and ≥55 years) risks of SS were evaluated. Results: The risk of SS was higher in patients with HCV than in those without chronic viral hepatitis (OR = 2.49, 95% CI = 2.16-2.86). Conversely, HBV infection was not associated with SS (OR = 1.10, 95% CI = 0.98-1.24). Younger HCV patients were at a higher risk for SS (<55 years: OR = 3.37, 95% CI = 2.62-4.35; ≥55 years: OR = 2.20, 95% CI = 1.84-2.62). Men with HCV were at a greater risk for SS (women: OR = 2.26, 95% CI = 1.94-2.63; men: OR = 4.22, 95% CI = 2.90-6.16). Only men with chronic HBV exhibited a higher risk of SS (OR = 1.61, 95% CI = 1.21-2.14). Conclusion: HCV infection was associated with SS; however, HBV only associated with SS in men.en_US
dc.rightsMahidol Universityen_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleAssociation of Sjögrens syndrome in patients with chronic hepatitis virus infection: A population-based analysisen_US
Appears in Collections:Scopus 2016-2017

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