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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/43065
Title: Thailandins A and B, New Polyene Macrolactone Compounds Isolated from Actinokineospora bangkokensis Strain 44EHW<sup>T</sup>, Possessing Antifungal Activity against Anthracnose Fungi and Pathogenic Yeasts
Authors: Bungonsiri Intra
Anja Greule
Andreas Bechthold
Jirayut Euanorasetr
Thomas Paululat
Watanalai Panbangred
Mahidol University
Universität Freiburg im Breisgau
Universitat Siegen
Keywords: Agricultural and Biological Sciences;Chemistry
Issue Date: 29-Jun-2016
Citation: Journal of Agricultural and Food Chemistry. Vol.64, No.25 (2016), 5171-5179
Abstract: © 2016 American Chemical Society. Two new polyene macrolactone antibiotics, thailandins A, 1, and B, 2, were isolated from the fermentation broth of rhizosphere soil-associated Actinokineospora bangkokensis strain 44EHWT. The new compounds from this strain were purified using semipreparative HPLC and Sephadex LH-20 gel filtration while following an antifungal activity guided fractionation. Their structures were elucidated through spectroscopic techniques including UV, HR-ESI-MS, and NMR. These compounds demonstrated broad spectrum antifungal activity against fungi causing anthracnose disease (Colletotrichum gloeosporioides DoA d0762, Colletotrichum gloeosporiodes DoA c1060, and Colletotrichum capsici DoA c1511) as well as pathogenic yeasts (Candida albicans MT 2013/1, Candida parasilopsis DKMU 434, and Cryptococcus neoformans MT 2013/2) with minimum inhibitory concentrations ranging between 16 and 32 μg/mL. This is the first report of polyene antibiotics produced by Actinokineospora species as bioactive compounds against anthracnose fungi and pathogenic yeast strains.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84976628483&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/43065
ISSN: 15205118
00218561
Appears in Collections:Scopus 2016-2017

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