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dc.contributor.authorRoberto Amatoen_US
dc.contributor.authorOlivo Miottoen_US
dc.contributor.authorCharles J. Woodrowen_US
dc.contributor.authorJacob Almagro-Garciaen_US
dc.contributor.authorIpsita Sinhaen_US
dc.contributor.authorSusana Campinoen_US
dc.contributor.authorDaniel Meaden_US
dc.contributor.authorEleanor Druryen_US
dc.contributor.authorMihir Kekreen_US
dc.contributor.authorMandy Sandersen_US
dc.contributor.authorAlfred Amambua-Ngwaen_US
dc.contributor.authorChanaki Amaratungaen_US
dc.contributor.authorLucas Amenga-Etegoen_US
dc.contributor.authorVoahangy Andrianaranjakaen_US
dc.contributor.authorTobias Apinjohen_US
dc.contributor.authorElizabeth Ashleyen_US
dc.contributor.authorSarah Auburnen_US
dc.contributor.authorGordon A. Awandareen_US
dc.contributor.authorVito Barakaen_US
dc.contributor.authorAlyssa Barryen_US
dc.contributor.authorMaciej F. Bonien_US
dc.contributor.authorSteffen Borrmannen_US
dc.contributor.authorTeun Bousemaen_US
dc.contributor.authorOralee Branchen_US
dc.contributor.authorPeter C. Bullen_US
dc.contributor.authorKesinee Chotivanichen_US
dc.contributor.authorDavid J. Conwayen_US
dc.contributor.authorAlister Craigen_US
dc.contributor.authorNicholas P. Dayen_US
dc.contributor.authorAbdoulaye Djimdéen_US
dc.contributor.authorChristiane Doleceken_US
dc.contributor.authorArjen M. Dondorpen_US
dc.contributor.authorChris Drakeleyen_US
dc.contributor.authorPatrick Duffyen_US
dc.contributor.authorDiego F. Echeverryen_US
dc.contributor.authorThomas G. Egwangen_US
dc.contributor.authorRick M. Fairhursten_US
dc.contributor.authorAbul Faizen_US
dc.contributor.authorCaterina I. Fanelloen_US
dc.contributor.authorTran Tinh Hienen_US
dc.contributor.authorAbraham Hodgsonen_US
dc.contributor.authorMallika Imwongen_US
dc.contributor.authorDeus Ishengomaen_US
dc.contributor.authorPharath Limen_US
dc.contributor.authorChanthap Lonen_US
dc.contributor.authorJutta Marfurten_US
dc.contributor.authorKevin Marshen_US
dc.contributor.authorMayfong Mayxayen_US
dc.contributor.authorPascal Michonen_US
dc.contributor.authorVictor Mobegien_US
dc.contributor.authorOlugbenga A. Mokuoluen_US
dc.contributor.authorJacqui Montgomeryen_US
dc.contributor.authorIvo Muelleren_US
dc.contributor.authorMyat Phone Kyawen_US
dc.contributor.authorPaul N. Newtonen_US
dc.contributor.authorFrancois Nostenen_US
dc.contributor.authorRintis Noviyantien_US
dc.contributor.authorAlexis Nzilaen_US
dc.contributor.authorHarold Ochollaen_US
dc.contributor.authorAbraham Oduroen_US
dc.contributor.authorMarie Onyambokoen_US
dc.contributor.authorJean Bosco Ouedraogoen_US
dc.contributor.authorAung Pyae P. Phyoen_US
dc.contributor.authorChristopher Ploween_US
dc.contributor.authorRic N. Priceen_US
dc.contributor.authorSasithon Pukrittayakameeen_US
dc.contributor.authorMilijaona Randrianarivelojosiaen_US
dc.contributor.authorPascal Ringwalden_US
dc.contributor.authorLastenia Ruizen_US
dc.contributor.authorDavid Saundersen_US
dc.contributor.authorAlex Shayoen_US
dc.contributor.authorPeter Sibaen_US
dc.contributor.authorShannon Takala-Harrisonen_US
dc.contributor.authorThuy Nhien N. Thanhen_US
dc.contributor.authorVandana Thathyen_US
dc.contributor.authorFederica Verraen_US
dc.contributor.authorJason Wendleren_US
dc.contributor.otherWellcome Trust Sanger Instituteen_US
dc.contributor.otherWellcome Trust Centre for Human Geneticsen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherNuffield Department of Clinical Medicineen_US
dc.contributor.otherMedical Research Council Laboratories Gambiaen_US
dc.contributor.otherNational Institute of Allergy and Infectious Diseasesen_US
dc.contributor.otherNavrongo Health Research Centeren_US
dc.contributor.otherInstitut Pasteur de Madagascaren_US
dc.contributor.otherUniversity of Bueaen_US
dc.contributor.otherMenzies School of Health Researchen_US
dc.contributor.otherUniversity of Ghanaen_US
dc.contributor.otherNational Institute for Medical Research Tangaen_US
dc.contributor.otherUniversiteit Antwerpenen_US
dc.contributor.otherWalter and Eliza Hall Institute of Medical Researchen_US
dc.contributor.otherUniversity of Melbourneen_US
dc.contributor.otherUniversity of Oxforden_US
dc.contributor.otherKenya Medical Research Instituteen_US
dc.contributor.otherUniversität Tübingenen_US
dc.contributor.otherLondon School of Hygiene & Tropical Medicineen_US
dc.contributor.otherNYU School of Medicineen_US
dc.contributor.otherLiverpool School of Tropical Medicineen_US
dc.contributor.otherUniversity of Bamakoen_US
dc.contributor.otherOxford University Clinical Research Uniten_US
dc.contributor.otherPurdue Universityen_US
dc.contributor.otherCentro Internacional de Entrenamiento e Investigaciones Medicasen_US
dc.contributor.otherMed Biotech Laboratories Ugandaen_US
dc.contributor.otherMalaria Research Group and Dev Care Foundationen_US
dc.contributor.otherNational Centre for Parasitology, Entomology and Malaria Controlen_US
dc.contributor.otherArmed Forces Research Institute of Medical Sciences, Thailanden_US
dc.contributor.otherLao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU)en_US
dc.contributor.otherUniversity of Health Sciencesen_US
dc.contributor.otherDivine Word Universityen_US
dc.contributor.otherUniversity of Ilorinen_US
dc.contributor.otherPennsylvania State Universityen_US
dc.contributor.otherMinistry of Healthen_US
dc.contributor.otherShoklo Malaria Research Uniten_US
dc.contributor.otherEijkman Institute for Molecular Biologyen_US
dc.contributor.otherKing Fahd University of Petroleum and Mineralsen_US
dc.contributor.otherMalawi-Liverpool-Wellcome Trusten_US
dc.contributor.otherUniversite de Kinshasaen_US
dc.contributor.otherInstitut de Recherche en Sciences de la Santéen_US
dc.contributor.otherUniversity of Maryland School of Medicineen_US
dc.contributor.otherOrganisation Mondiale de la Santeen_US
dc.contributor.otherUniversidad Nacional de la Amazonia Peruana, Iquitosen_US
dc.contributor.otherUniversity of Dodomaen_US
dc.contributor.otherPapua New Guinea Institute of Medical Researchen_US
dc.date.accessioned2018-12-11T02:18:05Z
dc.date.accessioned2019-03-14T08:04:08Z-
dc.date.available2018-12-11T02:18:05Z
dc.date.available2019-03-14T08:04:08Z-
dc.date.issued2016-03-04en_US
dc.identifier.citationeLife. Vol.5, No.MARCH2016 (2016)en_US
dc.identifier.issn2050084Xen_US
dc.identifier.other2-s2.0-84961932806en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84961932806&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/43071-
dc.description.abstract© 2016, eLife Sciences Publications Ltd. All rights reserved. The current epidemic of artemisinin resistant Plasmodium falciparum in Southeast Asia is the result of a soft selective sweep involving at least 20 independent kelch13 mutations. In a large global survey, we find that kelch13 mutations which cause resistance in Southeast Asia are present at low frequency in Africa. We show that African kelch13 mutations have originated locally, and that kelch13 shows a normal variation pattern relative to other genes in Africa, whereas in Southeast Asia there is a great excess of non-synonymous mutations, many of which cause radical amino-acid changes. Thus, kelch13 is not currently undergoing strong selection in Africa, despite a deep reservoir of variations that could potentially allow resistance to emerge rapidly. The practical implications are that public health surveillance for artemisinin resistance should not rely on kelch13 data alone, and interventions to prevent resistance must account for local evolutionary conditions, shown by genomic epidemiology to differ greatly between geographical regions.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84961932806&origin=inwarden_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.subjectImmunology and Microbiologyen_US
dc.titleGenomic epidemiology of artemisinin resistant malariaen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.7554/eLife.08714en_US
Appears in Collections:Scopus 2016-2017

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