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Title: Protective effects of a diarylheptanoid from Curcuma comosa against hydrogen peroxide-induced astroglial cell death
Authors: Jaturavit Vattanarongkup
Pawinee Piyachaturawat
Patoomratana Tuchinda
Pimtip Sanvarinda
Yupin Sanvarinda
Nattinee Jantaratnotai
Mahidol University
Keywords: Biochemistry, Genetics and Molecular Biology;Chemistry
Issue Date: 18-May-2016
Citation: Planta Medica. Vol.82, No.17 (2016), 1456-1462
Abstract: © Georg Thieme Verlag KG. Oxidative stress is one of the major mechanisms causing neuronal and astroglial cell death in various neurological disorders such as Alzheimer's disease, Parkinson's disease, and brain ischemia. Two diarylheptanoids, (3R)-1,7-diphenyl-(4E,6E)-4,6-heptadien-3-ol (ASPP 049) and (3S)-7-(3,4-dihydroxyphenyl)-1-phenyl-(1E)-1-hepten-3-ol (ASPP 092), isolated from Curcuma comosa were investigated for cytoprotective effects on C6 astroglial cells using hydrogen peroxide (H2O2) exposure as a model of oxidative stress. ASPP 092 demonstrated free radical scavenging activity comparable to that of vitamin C, while ASPP 049 showed no antioxidant activity. Treatment with H2O2 at 400 μM for 12 h caused 79% C6 astroglial cell death which was significantly reduced to 37% by pretreatment with ASPP 092 (5 μM). In addition, ASPP 092 attenuated the increase in reactive oxygen species production and the decrease in total glutathione level induced by H2O2. The mechanism of ASPP 092 protection against H2O2-induced apoptotic signaling appeared to involve prevention of increase in the level of phosphorylated p53 and the Bax/Bcl-2 ratio as well as cleaved caspase-3. These findings provide new evidence that the diarylheptanoid ASPP 092 from C. comosa possesses antiapoptotic properties and could be further developed as a potential treatment for oxidative stress-related neuronal diseases.
ISSN: 14390221
Appears in Collections:Scopus 2016-2017

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