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dc.contributor.authorThomas J. Petoen_US
dc.contributor.authorRupam Tripuraen_US
dc.contributor.authorSue J. Leeen_US
dc.contributor.authorThomas Althausen_US
dc.contributor.authorSusanna Dunachieen_US
dc.contributor.authorChea Nguonen_US
dc.contributor.authorMehul Dhordaen_US
dc.contributor.authorCholrawee Promnarateen_US
dc.contributor.authorJeremy Chalken_US
dc.contributor.authorMallika Imwongen_US
dc.contributor.authorLorenz Von Seidleinen_US
dc.contributor.authorNicholas P. Dayen_US
dc.contributor.authorArjen M. Dondorpen_US
dc.contributor.authorNicholas J. Whiteen_US
dc.contributor.authorYoel Lubellen_US
dc.contributor.otherMahidol Universityen_US
dc.contributor.otherUniversity of Oxforden_US
dc.contributor.otherNational Center for Parasitology, Entomology and Malaria Controlen_US
dc.date.accessioned2018-12-11T01:58:12Z
dc.date.accessioned2019-03-14T08:04:13Z-
dc.date.available2018-12-11T01:58:12Z
dc.date.available2019-03-14T08:04:13Z-
dc.date.issued2016-07-01en_US
dc.identifier.citationPLoS ONE. Vol.11, No.7 (2016)en_US
dc.identifier.issn19326203en_US
dc.identifier.other2-s2.0-84978647643en_US
dc.identifier.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84978647643&origin=inwarden_US
dc.identifier.urihttp://repository.li.mahidol.ac.th/dspace/handle/123456789/43143-
dc.description.abstract© 2016 Peto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background: Subclinical infections in endemic areas of Southeast Asia sustain malaria transmission. These asymptomatic infections might sustain immunity against clinical malaria and have been considered benign for the host, but if they are associated with chronic low-grade inflammation this could be harmful. We conducted a case-control study to explore the association between subclinical malaria and C-reactive protein (CRP), an established biomarker of inflammation. Methods: Blood samples from asymptomatic villagers in Pailin, Western Cambodia were tested for malaria by high-volume ultra-sensitive polymerase chain reaction (uPCR) to determine the Plasmodium species. Plasma CRP concentration was measured in 328 individuals with parasitaemia (cases) and compared with: i) the same individual's value at the first time point when they had no detectable parasites (n = 282); and ii) age- sex- and village-matched controls (n = 328) free of Plasmodium infection. Plasma CRP concentrations were compared against thresholds of 3mg/L and 10mg/L. Subgroup analysis was carried out for cases with P vivax and P falciparum mono-infections. Results: Median plasma CRP level for all samples was 0.59mg/L (interquartile range: 0.24-1.64mg/ L). CRP concentrations were higher in parasitaemic individuals compared with same-person-controls (p = 0.050); and matched-controls (p = 0.025). 4.9% of samples had CRP concentrations above 10mg/L and 14.6% were above 3mg/L. Cases were more likely to have plasma CRP concentrations above these thresholds than age/sex matched controls, odds ratio 3.5 (95%CI 1.5-9.8) and 1.8 (95%CI 1.1-2.9), respectively. Amongst cases, parasite density and CRP were positively correlated (p<0.001), an association that remained significant when controlling for age and fever. Individuals with P.vivax mono-infections had the highest plasma CRP concentrations with the greatest association with parasitaemia. Discussion: In this setting persistent malaria infections in asymptomatic individuals were associated with moderately elevated plasma CRP concentrations; chiefly evident in cases with P.vivax mono-infections. As well as interrupting malaria transmission within the community, treatment of asymptomatic malaria infections, in particular radical cure of vivax malaria, may benefit the health of infected individuals.en_US
dc.rightsMahidol Universityen_US
dc.source.urihttps://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84978647643&origin=inwarden_US
dc.subjectAgricultural and Biological Sciencesen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleAssociation between subclinical malaria infection and inflammatory host response in a pre-elimination settingen_US
dc.typeArticleen_US
dc.rights.holderSCOPUSen_US
dc.identifier.doi10.1371/journal.pone.0158656en_US
Appears in Collections:Scopus 2016-2017

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