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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/43163
Title: Acquisition and Longevity of Antibodies to Plasmodium vivax Preerythrocytic Antigens in Western Thailand
Authors: Rhea J. Longley
Arturo Reyes-Sandoval
Eduardo Montoya-Díaz
Susanna Dunachie
Chalermpon Kumpitak
Wang Nguitragool
Ivo Mueller
Jetsumon Sattabongkot
Mahidol University
Walter and Eliza Hall Institute of Medical Research
University of Melbourne
Nuffield Department of Clinical Medicine
University of Oxford
Instituto de Salud Global de Barcelona
Keywords: Biochemistry, Genetics and Molecular Biology;Immunology and Microbiology
Issue Date: 1-Feb-2016
Citation: Clinical and Vaccine Immunology. Vol.23, No.2 (2016), 117-124
Abstract: Copyright © 2016 American Society for Microbiology. All Rights Reserved. Plasmodium vivax is now the dominant Plasmodium species causing malaria in Thailand, yet little is known about naturally acquired immune responses to this parasite in this low-transmission region. The preerythrocytic stage of the P. vivax life cycle is considered an excellent target for a malaria vaccine, and in this study, we assessed the stability of the seropositivity and the magnitude of IgG responses to three different preerythrocytic P. vivax proteins in two groups of adults from a region of western Thailand where malaria is endemic. These individuals were enrolled in a yearlong cohort study, which comprised one group that remained P. vivax free (by quantitative PCR [qPCR] detection, no31) and another that experienced two or more blood-stage P. vivax infections during the year of follow up (no31). Despite overall low levels of seropositivity, IgG positivity and magnitude were long-lived over the 1-year period in the absence of qPCR-detectable blood-stage P. vivax infections. In contrast, in the adults with two or more P. vivax infections during the year, IgG positivity was maintained, but the magnitude of the response to P. vivax circumsporozoite protein 210 (CSP210) decreased over time. These findings demonstrate that long-term humoral immunity can develop in low-transmission regions.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84958629564&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/43163
ISSN: 1556679X
15566811
Appears in Collections:Scopus 2016-2017

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