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dc.contributor.authorJirayut Euanorasetren_US
dc.contributor.authorMayura Junhomen_US
dc.contributor.authorSrisurang Tantimavanichen_US
dc.contributor.authorOnanong Vorasinen_US
dc.contributor.authorBamroong Munyooen_US
dc.contributor.authorPatoomratana Tuchindaen_US
dc.contributor.authorWatanalai Panbangreden_US
dc.contributor.otherMahidol Universityen_US
dc.identifier.citationJournal of Asian Natural Products Research. Vol.18, No.5 (2016), 462-474en_US
dc.description.abstract© 2016 Informa UK Limited, trading as Taylor & Francis Group. Abstract: Altholactone exhibited the anti-fungal activity with a high MIC value of 128 μg ml−1against Cryptococcus neoformans and Saccharomyces cerevisiae. Fifteen ester derivatives of altholactone 1–15 were modified by esterification and their structures were confirmed by spectroscopic methods. Most of the ester derivatives exhibited stronger anti-fungal activities than that of the precursor altholactone. 3-Bromo- and 2,4-dichlorobenzoates (7 and 15) exhibited the lowest minimal inhibitory concentration (MIC) values against C. neoformans at 16 μg ml−1,while the 4-bromo-, 4-iodo-, and 1-bromo-3-chlorobenzoates (11–13) displayed potent activity against S. cerevisiae with MIC values of 1 μg ml−1. In conclusion, this analysis indicates that the anti-fungal activity of altholactone is enhanced by addition of halogenated benzoyl group to the 3-OH group.en_US
dc.rightsMahidol Universityen_US
dc.subjectBiochemistry, Genetics and Molecular Biologyen_US
dc.titleHalogenated benzoate derivatives of altholactone with improved anti-fungal activityen_US
Appears in Collections:Scopus 2016-2017

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