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Please use this identifier to cite or link to this item: http://repository.li.mahidol.ac.th/dspace/handle/123456789/43212
Title: Plasma lipidomics as a tool for diagnosis of extrahepatic cholangiocarcinoma in biliary strictures: A pilot study
Authors: Varayu Prachayakul
Phataraphong Thearavathanasingha
Chanitra Thuwajit
Sittiruk Roytrakul
Janthima Jaresitthikunchai
Peti Thuwajit
Mahidol University
Thailand National Center for Genetic Engineering and Biotechnology
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jan-2016
Citation: Asian Pacific Journal of Cancer Prevention. Vol.17, No.8 (2016), 4155-4162
Abstract: Biliary obstruction is a common clinical manifestation of various conditions, including extrahepatic cholangiocarcinoma. However, a screening test for diagnosis of extrahepatic cholangiocarcinoma in patients with biliary obstruction is not yet available. According to the rationale that the biliary system plays a major role in lipid metabolism, biliary obstruction may interfere with lipid profiles in the body. Therefore, plasma lipidomics may help indicate the presence or status of disease in biliary obstruction suspected extrahepatic cholangiocarcinoma. This study aimed to use of plasma lipidomics for diagnosis of extrahepatic cholangiocarcinoma in patients with biliary obstruction. Plasma from healthy volunteers, patients with benign biliary obstruction extrahepatic cholangiocarcinoma, and other related cancers were used in this study. Plasma lipids were extracted and lipidomic analysis was performed using matrix-assisted laser desorption ionization time-of-flight mass spectrometry. Lipid profiles from extrahepatic cholangiocarcinoma patients showed significant differences from both normal and benign biliary obstruction conditions, with no distinction between the latter two. Relative intensity of the selected lipid mass was able to successfully differentiate all extrahepatic cholangiocarcinoma samples from patient samples taken from healthy volunteers, patients with benign biliary obstruction, and patients with other related cancers. In conclusion, lipidomics is a non-invasive method with high sensitivity and specificity for identification of extrahepatic cholangiocarcinoma in patients with biliary obstruction.
URI: https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84988351552&origin=inward
http://repository.li.mahidol.ac.th/dspace/handle/123456789/43212
ISSN: 15137368
Appears in Collections:Scopus 2016-2017

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