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Title: Comparative mitochondrial genome analysis of Pythium insidiosum and related oomycete species provides new insights into genetic variation and phylogenetic relationships
Authors: Sithichoke Tangphatsornruang
Panthita Ruang-areerate
Duangjai Sangsrakru
Thidarat Rujirawat
Tassanee Lohnoo
Weerayuth Kittichotirat
Preecha Patumcharoenpol
Laura J. Grenville-Briggs
Theerapong Krajaejun
Thailand National Center for Genetic Engineering and Biotechnology
Mahidol University
King Mongkut s University of Technology Thonburi
Sveriges lantbruksuniversitet
Keywords: Biochemistry, Genetics and Molecular Biology
Issue Date: 1-Jan-2016
Citation: Gene. Vol.575, No.1 (2016), 34-41
Abstract: © 2015 Elsevier B.V.. Oomycetes are eukaryotic microorganisms, which are phylogenetically distinct from the true-fungi, which they resemble morphologically. While many oomycetes are pathogenic to plants, Pythium insidiosum is capable of infecting humans and animals. Mitochondrial (mt) genomes are valuable genetic resources for exploring the evolution of eukaryotes. During the course of 454-based nuclear genome sequencing, we identified a complete 54.9. kb mt genome sequence, containing 2 large inverted repeats, from P. insidiosum. It contains 65 different genes (including 2 ribosomal RNA genes, 25 transfer RNA genes and 38 genes encoding NADH dehydrogenases, cytochrome b, cytochrome c oxidases, ATP synthases, and ribosomal proteins). Thirty-nine of the 65 genes have two copies, giving a total of 104 genes. A set of 30 conserved protein-coding genes from the mt genomes of P. insidiosum, 11 other oomycetes, and 2 diatoms (outgroup) were used for phylogenetic analyses. The oomycetes can be classified into 2 phylogenetic groups, in relation to their taxonomic lineages: Saprolegnialean and Peronosporalean. P. insidiosum is more closely related to Pythium ultimum than other oomycetes. In conclusion, the complete mt genome of P. insidiosum was successfully sequenced, assembled, and annotated, providing a useful genetic resource for exploring the biology and evolution of P. insidiosum and other oomycetes.
ISSN: 18790038
Appears in Collections:Scopus 2016-2017

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