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|Title:||Cytotoxic lanostanes from fruits of Garcinia wallichii Choisy (Guttiferae)|
Chulabhorn Research Institute
National Park, Wildlife and Plant Conservation Department, Thailand
|Keywords:||Biochemistry, Genetics and Molecular Biology;Chemistry|
|Citation:||Bioorganic and Medicinal Chemistry Letters. Vol.26, No.23 (2016), 5773-5779|
|Abstract:||© 2016 Elsevier Ltd Five new lanostanes, wallichinanes A–E (1–5) together with a known lanostane derivative 6 were isolated from the cytotoxic hexanes extract of fruits of Garcinia wallichii Choisy (Guttiferae). The structures of the isolated compounds were established by analysis of spectroscopic data, X-ray diffraction technique as well as comparison with the literature data. The cytotoxicity of all isolated compounds against a panel of cultured cancer cell lines was evaluated. Compound 4 exhibited good cytotoxicity with ED50values ranging from 3.91 to 7.63 μM.|
|Appears in Collections:||Scopus 2016-2017|
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