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Title: The draft genome sequence of Actinokineospora bangkokensis 44EHW<sup>T</sup>reveals the biosynthetic pathway of the antifungal thailandin compounds with unusual butylmalonyl-CoA extender units
Authors: Anja Greule
Bungonsiri Intra
Stephan Flemming
Marcel G.E. Rommel
Watanalai Panbangred
Andreas Bechthold
Universität Freiburg im Breisgau
Mahidol University
Keywords: Chemistry;Medicine
Issue Date: 1-Nov-2016
Citation: Molecules. Vol.21, No.11 (2016)
Abstract: © 2016 by the authors; licensee MDPI. We report the draft genome sequence of Actinokineospora bangkokensis 44EHWT, the producer of the antifungal polyene compounds, thailandins A and B. The sequence contains 7.45 Mb, 74.1% GC content and 35 putative gene clusters for the biosynthesis of secondary metabolites. There are three gene clusters encoding large polyketide synthases of type I. Annotation of the ORF functions and targeted gene disruption enabled us to identify the cluster for thailandin biosynthesis. We propose a plausible biosynthetic pathway for thailandin, where the unusual butylmalonyl-CoA extender unit is incorporated and results in an untypical side chain.
ISSN: 14203049
Appears in Collections:Scopus 2016-2017

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