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Title: Development of tunable biodegradable polyhydroxyalkanoates microspheres for controlled delivery of tetracycline for treating periodontal disease
Authors: Nootchanartch Panith
Apinya Assavanig
Sittiwat Lertsiri
Magnus Bergkvist
Rudee Surarit
Nuttawee Niamsiri
Mahidol University
University at Albany State University of New York
Keywords: Chemistry;Materials Science
Issue Date: 10-Nov-2016
Citation: Journal of Applied Polymer Science. Vol.133, No.42 (2016)
Abstract: © 2016 Wiley Periodicals, Inc. This article was aimed at preparation and characterization of drug delivery carriers made from biodegradable polyhydroxyalkanoates (PHAs) for slow release of tetracycline (TC) for periodontal treatment. Four PHA variants; polyhydroxybutyrate (PHB), poly(hydroxybutyrate-co-hydroxyvalerate) with 5, 12, and 50% hydroxyvalerate were used to formulate TC-loaded PHA microspheres by double emulsion-solvent evaporation method. We also compared the effect of different molecular weight (Mw) of polyvinyl alcohol (PVA) acting as surface stabilizer on particle size, drug loading, encapsulation efficiency, and drug release profile. The TC-loaded PHA microspheres exhibited microscale and nanoscale spherical morphology under scanning electron microscopy. Among formulations, TC-loaded PHB:low Mw PVA demonstrated the highest TC loading with slow release behavior. Our results showed that the release rate from PHA microspheres was influenced by both the type of PHA and Mw of PVA stabilizer. Lastly, TC-loaded PHB microspheres showed efficient killing activity against periodontitis-causing bacteria, suggesting its potential application for treating periodontal disease. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 44128.
ISSN: 10974628
Appears in Collections:Scopus 2016-2017

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